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What is Gynecologic Cancer?

Gynecologic cancer refers to cancers affecting the female reproductive system. The five primary types include ovarian, cervical, endometrial, vulvar, and vaginal cancers. Each type presents distinct characteristics, yet early detection remains critical for effective treatment.

Types of Gynecologic Cancers

The six primary types of gynecologic cancers include:

1. Cervical:Originates in the cervix, the lower end of the uterus leading to the vagina.
2. Ovarian:Begins in the ovaries, the female reproductive glands located on either side of the uterus.
3. Uterine (Endometrial):Arises in the uterus, the organ where fetal development occurs.
4. Vaginal:Develops in the vagina, the channel between the uterus and the outside of the body.
5. Vulvar:Occurs on the vulva, the external part of the female genitalia.
6. Tubal:Begins in the fallopian tubes.

While treatment options will vary according to cancer type, tumor grade, and cancer stage, surgery is nearly always a crucial component. Many treatment plans also include chemotherapy and/or radiation therapy. At El Portal Cancer Centers, our team works collaboratively—our surgeon, medical oncologists, and radiation oncologists join forces to ensure you receive the most comprehensive and integrated care possible.

What are the Risk Factors?

All women face a risk of developing gynecologic cancers, and this risk increases with age. While some risk factors are controllable, others are not.

Commonly associated controllable risk factors include:

• Human papillomavirus (HPV) infection
• Long-term oral contraceptive use
• Being overweight or obese
• Poor nutrition
• Smoking
• Exposure to diethylstilbestrol (DES)
• Human immunodeficiency virus (HIV/AIDS) infection

In addition to making lifestyle changes—such as maintaining a balanced diet and exercising regularly—discussing your concerns with your doctor can lead to proactive measures for risk reduction, like the HPV vaccine.

Unfortunately, some risk factors are beyond your control, including age, race, and family history. It’s essential to remember that many women with risk factors never develop gynecologic cancer. If there is a family history of certain cancers, consider discussing genetic testing options with your healthcare provider.

What Symptoms Should I Watch For?

Being aware of potential symptoms can help facilitate early detection. Some symptoms include:

• Abnormal vaginal bleeding or discharge
• Pelvic pain
• Pain during intercourse
• Frequent or urgent bowel changes
• Bloating or a feeling of fullness

If you experience any of these symptoms for more than a month, we strongly recommend scheduling an appointment with your gynecologist. Regular check-ups are vital, even in the absence of symptoms.

What Should I Ask My Doctor?

Establishing an open dialogue with your doctor is crucial for understanding gynecologic cancer. Consider asking:

• What is a Pap test, and why is it necessary?
• How often should I schedule Pap tests?
• What do my Pap results mean?
• Is an HPV test appropriate for me?
• When can I discontinue Pap testing?

How are Gynecologic Cancers Treated? A treatment plan for gynecologic cancers is tailored to each individual. Surgery is generally the first step, often followed by a combination of chemotherapy and/or radiation therapy. Our specialists collaborate closely to ensure every aspect of your treatment is addressed thoroughly.

Are All Gynecologic Conditions Cancerous? Not all gynecological conditions are cancerous. Many benign conditions may resolve on their own or can be treated effectively. Examples include fibroids, ovarian cysts, and pelvic infections, each of which may require specific management based on severity.

Robotic-Assisted Surgery and Gynecologic Care

At El Portal Cancer Centers, we offer robotic-assisted surgery, a minimally invasive option that reduces recovery time and minimizes surgical trauma. This advanced approach allows for precise procedures through smaller incisions, resulting in less pain and scarring, lower infection risks, and quicker returns to daily activities.

Minimally Invasive Surgery Options

• Laparoscopic Surgery:A gold standard in gynecologic procedures, this technique involves small incisions and utilizes a camera to guide the surgeon.\
• Robotic-Assisted Surgery: A New Era in Gynecologic CareThe landscape of gynecologic surgery has transformed significantly. At El Portal Cancer Centers (EPCC), we are proud to offer robotic-assisted surgery, a forward-thinking option that allows for minimally invasive procedures with enhanced precision and improved outcomes. This advanced technique utilizes specialized robotic instruments coupled with a unique 3D high-definition view of the surgical site, empowering your surgeon to perform with remarkable accuracy.

Diagnosing Multiple Myeloma typically involves several steps:

1. Medical History and Physical Examination:
   • Your healthcare provider will start by reviewing your medical history, discussing symptoms you’ve experienced, and conducting a thorough physical examination to check for signs of the disease, such as bone tenderness or swelling.
2. Blood Tests:
   • Blood tests are essential in diagnosing Multiple Myeloma. Common tests include:
     • Complete Blood Count (CBC): Monitors levels of red blood cells, white blood cells, and platelets.
     • Blood Chemistry Tests: Assess kidney function and other vital parameters.
     • Serum Protein Electrophoresis (SPEP): Identifies abnormal proteins (monoclonal proteins) produced by myeloma cells.
     • Free Light Chain Assay: Measures the levels of free light chains in the blood and can indicate the presence of myeloma.

3. Urine Tests:
   • A 24-hour urine collection may be performed to check for Bence Jones protein, a type of light chain protein released by myeloma cells.
4. Bone Marrow Biopsy:
   • A definitive diagnosis often requires a bone marrow biopsy, where a small amount of bone marrow (usually from the hipbone) is extracted and analyzed for abnormal plasma cells.
5. Imaging Tests:
   • Imaging techniques such as X-rays, CT scans, or MRIs are used to assess bone damage or lesions caused by myeloma. These tests help identify areas of bone weakening or fractures.

While the exact cause of Multiple Myeloma remains unknown, several factors may increase the risk:

1. Age: The risk of developing Multiple Myeloma increases with age, most commonly affecting individuals over 65.
2. Gender: Men are more likely to develop Multiple Myeloma than women.
3. Race: African Americans have a higher incidence of Multiple Myeloma compared to Caucasian populations.
4. Family History: A family history of Multiple Myeloma or related plasma cell disorders may increase individual risk.
5. Certain Medical Conditions: Conditions such as monoclonal gammopathy of undetermined significance (MGUS) or other blood disorders can predispose individuals to myeloma.
6. Exposure to Chemicals: Long-term exposure to certain chemicals, such as benzene, and agricultural chemicals, may contribute to the development of myeloma.

Recognizing the signs and symptoms of Multiple Myeloma is crucial for early intervention:

1. Bone Pain: Persistent pain, particularly in the back, hips, or ribs, may indicate damage to the bones caused by myeloma lesions.
2. Fatigue: Anemia, caused by reduced red blood cell production, often leads to fatigue and weakness.
3. Frequent Infections: Compromised immune function due to myeloma can make patients more susceptible to infections.
4. Unexplained Weight Loss: Patients may experience unexplained weight loss with no changes in their regular diet or physical activity.

Treatment for Multiple Myeloma is generally tailored to individual patient needs and the disease’s specific characteristics. Here are the primary treatment options:

1. Chemotherapy: Chemotherapy remains a cornerstone of treatment for Multiple Myeloma. Regimens may include combinations such as:
   • Bortezomib (Velcade):A proteasome inhibitor that blocks protein degradation pathways in cancer cells.
   • Dexamethasone:A corticosteroid used in combination with other drugs to reduce inflammation and manage symptoms.
   • Lenalidomide (Revlimid):An immunomodulatory drug that enhances the immune response against myeloma cells.
2. Targeted Therapy: Targeted therapies focus specifically on cancerous cells, minimizing harm to normal cells:
   • Monoclonal Antibodies:Medications like daratumumab (Darzalex) are designed to target specific proteins on myeloma cells, leading to their destruction.
   • Carfilzomib (Kyprolis):A newer proteasome inhibitor used in patients with relapsed or refractory myeloma.
3. Immunotherapy: Immunotherapies use the body’s immune system to fight cancer:
   • Chimeric Antigen Receptor (CAR) T-Cell Therapy:This innovative approach involves modifying a patient’s T-cells to better recognize and attack myeloma cells. It has shown promise for some patients with difficult-to-treat myeloma.
4. Stem Cell Transplant: For eligible patients, stem cell transplant can provide an opportunity for long-term remission:
   • Autologous Stem Cell Transplant:This involves harvesting the patient’s own stem cells, administering high-dose chemotherapy to eliminate cancer cells, and then reinfusing the healthy stem cells.
5. Radiation Therapy: Radiation can be used to relieve pain or target specific areas affected by multiple myeloma, particularly in cases of localized disease or bone lesions.
6. Supportive Care: Supportive care plays a vital role in managing symptoms and improving quality of life. This may include medications for pain relief, management of anemia, hydration support, and nutritional counseling.

Receiving a prostate cancer diagnosis can be overwhelming, and there are important decisions to be made. It’s natural to have questions, and we are here to help you navigate your options and understand what lies ahead. You’ll learn about your cancer care team and what to expect as you embark on this journey.

What Type of Doctor Should You See First After a Prostate Cancer Diagnosis?

Typically, a urologist will perform the biopsy that confirms the presence of prostate cancer and assesses its aggressiveness. Following this initial diagnosis, we recommend scheduling a consultation with an oncologist. Our dedicated oncologists are well-versed in the latest treatment options, ensuring you receive therapies tailored specifically for you.

Your oncologist will help you understand the growth pattern of the cancer and how it may evolve moving forward. The biopsy results, combined with other diagnostic tests, will provide the necessary information to determine both the stage and grade of your prostate cancer.

Staging Prostate Cancer

Using the results from your biopsy and additional diagnostic tests, your oncologist will ascertain the stage of your prostate cancer. Further imaging or scans may be required to identify whether cancer cells have extended beyond the prostate.

Gleason Score and Grading

The Gleason score, included in your biopsy report, indicates how much the cancer cells have altered in various parts of the prostate. This grading aids in determining whether immediate treatment is necessary.

The Gleason score is a system used to grade prostate cancer based on how aggressive and likely it is to spread. It is determined by examining cancer cells under a microscope and assigning them a score from 1 to 5.

Grading:
1-2: Well-differentiated, least aggressive
3-4: Moderately differentiated
5: Poorly differentiated, most aggressive

Gleason scores are subject to interpretation and may vary slightly between pathologists. It is important to discuss your Gleason score with your healthcare provider to understand its implications and treatment options.

Preparing for Your First Oncology Appointment

Your first oncology appointment is essential for gathering important information, but it can be overwhelming. We suggest bringing a notebook or using your smartphone to take notes during the appointment. This will help you keep track of important details and any questions that arise.

We strongly encourage you to bring a friend or loved one for support. They can take notes, ask questions that might be on your mind, and provide reassurance.

Additionally, please bring your health records, including any prostate cancer test results, recent imaging scans, your insurance card, and a list of medications or supplements you’re currently taking.

Questions to Discuss with Your Oncologist

• How soon do I need to decide on a treatment plan?
• If “watchful waiting” is recommended, how often should I return for follow-up testing?
• What treatment options do you suggest when the time comes to proceed?
• What should I expect during future appointments?
• Are there lifestyle changes (in diet, exercise, rest, or stress management) I should consider?
• How should I manage any symptoms affecting my daily life?
• Are there any activities I should avoid or incorporate into my routine?
• Can I take nutritional supplements or vitamins to support my prostate health?
• Should my family and I consider genetic testing to check for hereditary risk?
• What supportive care resources are available through your practice or community organizations?

Feeling confident about your prostate cancer diagnosis and treatment plan is vital, even if it begins with watchful waiting. Many patients choose to seek a second opinion, and our oncologists are completely supportive of this decision. Insurance coverage for second opinions is often available, so we recommend contacting your insurance provider to verify your benefits before scheduling an appointment.

You Are Not Alone on Your Prostate Cancer Journey

At El Portal Comprehensive Cancer Centers, we are committed to supporting you throughout your entire journey. With convenient locations across Central California, we are here to offer you compassionate care and guidance every step of the way. Together, we will navigate this path to achieve the best possible outcome for your health and well-being.

A cancer diagnosis is a profound life event that impacts not only the individual diagnosed but also their entire family.

• Anxiety and Fear:
  The uncertainty surrounding diagnosis, prognosis, and treatment outcomes can induce intense anxiety and fear among family members. Children, in particular, may struggle to comprehend the situation, leading to heightened worries about losing a parent or feeling responsible for the illness. Adults may worry about the future, their loved one’s health, or their own ability to handle caregiving responsibilities.
• Guilt and Anger:
  Family members might experience guilt, feeling they should have detected the illness earlier or questioning whether their actions contributed to the situation. Anger can also surface—either directed at the illness, healthcare providers, or even oneself—potentially leading to emotional withdrawal or conflict within the family.
• Helplessness and Powerlessness:
  The inability to “fix” the situation often leaves family members feeling overwhelmed. They may grapple with a sense of helplessness, unsure how to provide meaningful support or maintain normalcy, which can foster feelings of frustration or despair.
• Risk of Mental Health Issues:
  Caregivers, especially spouses or primary caregivers, are at increased risk for depression, anxiety, and other mental health problems due to sustained emotional and physical stress. Recognizing early symptoms and seeking professional help can be vital in preventing more severe mental health consequences.
• Changes in Family Relationships:
  The illness can lead to shifting roles—children taking on more responsibilities or a partner assuming new caregiving duties—potentially causing tension or resentment. Communication about these changes is essential to maintain trust and emotional intimacy.

• Disrupted Routines and Daily Schedules:
  Treatment appointments, hospital stays, and recovery periods can disrupt established routines, affecting work, school, and household management. Flexibility and proactive planning are crucial to minimize stress and ensure essential needs are met.
• Financial Strain:
  The costs associated with cancer treatment (medications, therapies, travel expenses) can lead to significant financial hardship. Families may need to explore insurance options, financial assistance programs, or community resources to alleviate some of these burdens.
• Impact on Children’s Well-Being:
  Children’s educational progress and social development may suffer due to disrupted routines, emotional distress, or increased household responsibilities. Providing age-appropriate information, maintaining routines where possible, and offering emotional support can help children cope better.
• Physical Fatigue of Caregivers:
  The physical demands of caring—such as assisting with daily activities, managing medications, and providing emotional support—can lead to exhaustion, sleep disturbances, and physical health issues. Caregivers should seek respite care and prioritize self-care to sustain their health.

By understanding and addressing the broad spectrum of physical, emotional, and practical impacts, families can develop a resilient approach to facing cancer together. Seeking support early, maintaining open communication, and prioritizing self-care can empower family members to navigate this challenging journey more effectively.

Effective Communication: Open, honest, and age-appropriate dialogues help family members process their feelings and clarify misunderstandings. Establishing regular family meetings or check-ins can facilitate emotional sharing and problem-solving.

Seeking Support and Resources: Families should not hesitate to reach out for support. This includes friends, extended family, support groupspecific to cancer patients and their families, and mental health professionals. Counseling can provide coping tools and emotional relief.

Individualized Support and Care: Recognize that each family member reacts differently based on personality, coping style, and relationship to the patient. Tailoring support—whether through counseling, support groups, or practical assistance—is critical to addressing these diverse needs.

Additional Strategies for Coping:

Education: Learning about the specific cancer type and treatment options can lessen uncertainty.

Advocacy: Helping family members become educated advocates within healthcare settings fosters confidence and ensures their needs are addressed.

Resilience Building: Engaging in stress-reduction activities, mindfulness, or hobbies can bolster emotional resilience.

1. Promote Open and Age-Appropriate Communication

• • Use honest language suitable for the child’s age to explain the illness without causing unnecessary fear.
  • Encourage questions and listen actively to family members’ concerns.
  • Establish regular check-ins to share updates and emotional responses.

2. Enhance Emotional Resilience

• • Practice mindfulness, meditation, or relaxation techniques together as a family.
  • Engage in enjoyable activities that provide relief and normalcy, such as hobbies, outdoor walks, or creative arts.
  • Recognize and validate each family member’s feelings without judgment.

3. Foster Practical Planning and Organization

• • Create a family calendar that includes treatment schedules, appointments, and important deadlines.
  • Develop a caregiving plan that distributes responsibilities fairly and includes contingency plans for emergencies.
  • Keep important documents accessible, such as insurance papers and medical directives.

4. Self-Care for Caregivers and Family Members

• • Schedule regular breaks and time for personal activities to prevent burnout.
  • Prioritize sleep, nutritious eating, and physical activity whenever possible.
  • Seek peer support groups or counseling to share experiences and gain encouragement.

1. 5. Build and Utilize Support Networks

• • Reach out to friends, extended family, and community resources early.
  • Consider virtual support options if local groups are unavailable or if mobility is limited.
  • Involve trusted individuals in caregiving and emotional support roles to lighten the load.

6. Stay Informed and Advocate

• • Educate yourself about the specific cancer diagnosis, treatment options, and side effects.
  • Maintain open communication with healthcare providers to ask questions and express concerns.
  • Advocate for your family’s needs within the healthcare system to ensure comprehensive care.

Pros of Concurrent Treatment:

• Enhanced Effectiveness: Research indicates that combining chemotherapy with radiation therapy can enhance the overall effectiveness of treatment. This is particularly true for certain cancers, including brain, head and neck, gastrointestinal, bladder, and lung cancers. When these cancers are located in challenging areas of the body, concurrent treatment can improve the chances of successful outcomes.
• Coordinated Care: At El Portal Comprehensive Cancer Centers (EPCCC), our experienced team of board-certified medical oncologists and radiation oncologists work closely together to ensure that your treatment is well-coordinated. This collaborative approach helps to minimize potential interactions between therapies.

Cons of Concurrent Treatment:

• Increased Side Effects: While concurrent treatment can be more effective against cancer, it can also place added stress on your body. Patients often experience intensified side effects such as nausea, fatigue, pain, and hair loss. These heightened reactions can be challenging and require careful management.
• More Frequent Appointments: Receiving both chemotherapy and radiation at the same time typically involves more appointments in a shorter timeframe. This means additional monitoring, including scans and blood draws, which can add to the overall stress of the treatment process.

Given the potential challenges associated with concurrent treatment, many patients may find that their treatment plan recommends therapies to be administered sequentially rather than simultaneously. A comprehensive approach may include surgery, chemotherapy, radiation therapy, immunotherapy, or targeted therapy—either alone or in combination.

Neoadjuvant Therapy: When chemotherapy or radiation is administered before surgery, the goal is to shrink the tumor or eliminate cancer cells outside the primary tumor site. This is known as neoadjuvant therapy and can enhance the effectiveness of surgical intervention.

Adjuvant Therapy: Conversely, if chemotherapy or radiation is administered after surgery, it serves the purpose of targeting any residual cancer cells that may remain, thus reducing the risk of recurrence. This approach is called adjuvant therapy.

By spacing out treatments, your body has the opportunity to recover between therapies, often resulting in fewer and less severe side effects.

Conclusion

Navigating cancer treatment options can be overwhelming, and each patient’s circumstances are unique. It’s important to discuss your individual situation with your healthcare team to determine the best approach tailored to your needs. Understanding the pros and cons of concurrent treatment, as well as the benefits of sequential therapies, can empower you to make informed decisions about your care. Remember, you are not alone in this journey, and a supportive team is here to help guide you every step of the way.

The most critical warning sign of skin cancer is the appearance of a new spot on the skin or changes in an existing spot that seem abnormal. Following the A B C D E guidelines can help you identify the common signs of skin cancer:

• Asymmetry:One half of a mole (or birthmark) does not match the other half.
• Border:Edges are irregular, ragged, notched, or blurred.
• Color:The color is uneven, often featuring different shades of brown or black, along with patches of pink, red, white, or blue.
• Diameter:The spot is larger than 6 millimeters across (about the size of a pencil eraser).
• Evolving:The mole is changing in size, shape, color, or elevation. 

Skin cancer is typically identified first by a healthcare professional during an examination of an unusual area on the skin. However, determining whether it is cancerous requires removal and subsequent testing, known as a biopsy. This is the only reliable method to confirm a skin cancer diagnosis.

You may have your biopsy performed in a dermatologist’s office or as an outpatient procedure in a hospital or clinic, depending on the size and location of the abnormal area. Local anesthesia is usually administered to ensure your comfort.

There are four common types of skin biopsies:

• Punch Biopsy:A sharp, hollow tool is used to remove a circle of tissue from the abnormal area.
• Incisional Biopsy:A scalpel is employed to remove a portion of the growth.
• Excisional Biopsy:The entire growth and some surrounding tissue are removed with a scalpel.
• Shave Biopsy:A thin, sharp blade is used to shave off the abnormal growth.

If there is a possibility of melanoma, dermatologists will generally avoid simply shaving or cauterizing the growth. Instead, an excisional biopsy will be performed, or if the growth is too large, a tissue sample will be collected.

Upon receiving a biopsy confirmation of skin cancer, you will be referred to a specialized oncologist for further evaluation and care. Understanding the extent, or stage, of your cancer is crucial, whether you have melanoma or nonmelanoma skin cancer. Staging involves a meticulous assessment to determine how thick the tumor is and whether it has metastasized to other parts of the body. If the tumor is particularly thick, your doctor may recommend chest x-rays, blood tests, and imaging scans of the liver, bones, and brain.

Knowing the stage of your cancer enables your oncologist to:

• Assess the seriousness of your cancer and your chances for survival
• Formulate the most effective treatment plan for your unique situation
• Identify clinical trials that may present additional treatment options

In some cases, your oncologist may need to examine your lymph nodes to accurately stage the cancer. Surgical procedures may be part of the treatment plan to remove cancerous lymph nodes, which can aid in managing the disease.

Staging Criteria
Staging is based on several key factors:

• The size of the tumor
• How deeply it has penetrated below the surface of the skin
• Whether it has spread to nearby lymph nodes or other organs

Oncologists utilize Roman numerals I through IV to designate the cancer stage. Stage I indicates small tumors that are confined to their original site, while Stage IV signifies advanced cancer that has spread to distant sites in the body.

Nonmelanoma Skin Cancer Staging
The stages of nonmelanoma skin cancer are as follows:

• Stage 0: The cancer is localized to the top layer of skin, classified as carcinoma in situ.
• Stage I: The tumor measures 2 centimeters (approximately three-quarters of an inch) or smaller.
• Stage II: The tumor exceeds 2 centimeters in diameter.
• Stage III: The cancer has spread beyond the skin to underlying tissues such as cartilage, muscle, or bone, or to nearby lymph nodes, but not to distant locations.
• Stage IV: The cancer has metastasized to other areas in the body.

Melanoma Staging
The staging for melanoma specifically is defined as follows:

• Stage 0: Melanoma cells are confined to the outer layer of skin (epidermis) and have not invaded deeper tissues.
• Stage I: In Stage I, the melanoma is considered thin:
  • The tumor is no thicker than 1 millimeter (1/25 inch) and may show signs of ulceration (a scraped appearance).
  • Alternatively, the tumor measures between 1 and 2 millimeters thick without ulceration, and melanoma cells have not spread to nearby lymph nodes.
• Stage II: At this stage, the tumor is at least 1 millimeter thick:
  • It may be between 1 and 2 millimeters thick and present with ulceration.
  • Alternatively, the tumor may be greater than 2 millimeters thick, potentially with ulceration, but has not yet spread to nearby lymph nodes.
• Stage III: This indicates that melanoma has spread to nearby lymph nodes or to tissues just outside the original tumor without affecting the lymph nodes.
• Stage IV: At this advanced stage, melanoma cells have metastasized to other organs, lymph nodes, or distant skin areas.
• Recurrent: Recurrent disease indicates that cancer has returned after treatment, either in the original site or in a new location within the body.

There are various approaches to treating skin cancer, and your oncologist will work closely with you to determine the most effective combination of therapies based on the stage of cancer and your overall health. We at El Portal Comprehensive Cancer Centers are dedicated to providing you with comprehensive care tailored to your needs, ensuring you receive the support, guidance, and treatment necessary for your journey toward recovery.

Nonmelanoma Skin Cancer Treatments

In some cases, the entire nonmelanoma skin cancer may be removed during the biopsy, which means no further treatment is necessary. However, if additional treatment is required, your doctor will outline the available options.

There are six primary types of nonmelanoma skin cancer treatments, which may be used individually or in combination:

1. Surgery
2. Chemotherapy
3. Photodynamic therapy
4. Radiation therapy
5. Biologic therapy
6. Targeted therapy

Melanoma Skin Cancer Treatments

Melanoma treatment encompasses nearly all the same options as nonmelanoma skin cancer, with the exception of photodynamic therapy.

Skin Cancer Treatment Options

Your oncologist can provide detailed explanations of the following surgical techniques:

• Wide-Local Excision (WLE): This common approach involves numbing the area and surgically removing the cancer along with a margin of surrounding healthy skin. The margin is examined microscopically to ensure all cancer cells have been excised, and the required margin size will depend on the tumor’s dimensions. In some cases, nearby lymph nodes may also be removed.
• Mohs Surgery: This technique is particularly beneficial for skin cancer treatment. The surgeon numbs the area and removes thin layers of the tumor, examining each layer under a microscope for cancer cells. The process continues until no cancerous cells are detected, ensuring complete tumor removal while preserving as much healthy tissue as possible.
• Electrodesiccation and Curettage: This method is ideal for small basal cell skin cancers. The doctor numbs the area, removes the cancer using a curette (a spoon-shaped surgical instrument), and then employs an electric current to control bleeding and eliminate any remaining cancer cells. This procedure tends to be quick and straightforward.
• Cryosurgery: This option is suitable for patients who may not tolerate other surgical methods. Cryosurgery employs extreme cold, typically generated from liquid nitrogen, to treat early-stage or very thin skin cancer lesions. While effective, this approach may cause swelling and could damage nerves in the area, leading to temporary loss of sensation.
• Laser Surgery: This technique involves using a focused beam of light to target and destroy cancer cells. It is primarily utilized for superficial growths confined to the outer layer of skin.
• Skin Grafting: Occasionally, grafts are necessary to cover openings left by surgical removal. In this procedure, the surgeon numbs the area and removes a patch of healthy skin from another part of your body, such as the thigh, to cover the excised area. It is important to provide special care to the graft site during the healing process.
• Lymphadenectomy: This surgical procedure may be employed in the case of melanoma, wherein lymph nodes are removed for evaluation. The removed tissue is examined under a microscope for cancer cells.
• Sentinel Lymph Node Biopsy: During this procedure, the sentinel lymph node—the first node likely to receive cancer spread from the tumor—is surgically removed. A radioactive substance and/or blue dye is injected near the tumor site to track the flow to the lymph nodes. If no cancer cells are found in the sentinel node, additional nodes may not need to be excised, making this a useful technique within melanoma treatment plans.

Dr. Mahmoudieh has been a vital member of El Portal Comprehensive Cancer Centers since 2008, bringing over a decade of dedicated experience to patient care. Before joining our team, he served as the Director of the Prostate Brachytherapy Program at Kaiser Permanente in Sacramento and Roseville, demonstrating his leadership in advanced cancer treatments.

He earned his medical degree from the Albert Szent-Györgyi School of Medicine in Szeged, Hungary, in 1996. With a strong interest in treating head, neck, and breast cancers, Dr. Mahmoudieh specializes in cutting-edge techniques such as Image-Guided Radiation Therapy (IGRT) and Intensity-Modulated Radiation Therapy (IMRT). His expertise extends to treating cancers of the head and neck, lung, gastrointestinal tract, and prostate.

A committed professional, Dr. Mahmoudieh is a member of the American Society for Therapeutic Radiology and Oncology (ASTRO), reflecting his engagement with ongoing developments in cancer treatment and research. His compassionate approach and advanced skill set ensure that each patient receives personalized, state-of-the-art care.

Outside of his professional life, Dr. Mahmoudieh enjoys traveling with his son and daughter, as well as reading and playing racquetball, embracing a balanced and active lifestyle. His dedication to both his patients and his personal passions makes him a trusted partner in your journey toward health.

Dr. Elhanafy is a highly respected Associate Professor of Medical Physics and serves as the Chief Medical Physicist at El Portal Comprehensive Cancer Centers since July 2013. He earned his Ph.D. in Medical Physics from the University of Wisconsin, Madison—where he began his foundational training and completed his thesis—in 2013, building on his initial joining of the university in 1999.

 With specialized training in advanced radiation oncology techniques—such as Intensity-Modulated Radiation Therapy (IMRT), High-Dose Rate Brachytherapy (HDR), Stereotactic Radiosurgery (SRS), Total Body Irradiation (TBI), Quality Assurance, and Radiobiology—Dr. Elhanafy brings a wealth of expertise to patient care. His dedication to the field is evident through numerous published research articles, as well as awards recognizing his leadership in organizing conferences, training sessions, lectures, and workshops.

Beyond his impressive credentials, Dr. Elhanafy is deeply committed to advancing medical physics and ensuring the best possible outcomes for his patients. His compassionate approach, combined with his extensive knowledge, makes him a trusted partner in your cancer care journey.

Outside of his professional pursuits, he values spending quality time with his family, reflecting his genuine care and balance in life.

Dr. Ahuja is a distinguished, board-certified Medical Oncologist with extensive training in medical hematology. He has refined his expertise at renowned institutions such as Tata Memorial Hospital, UCLA School of Medicine, and Roswell Park, under the mentorship of esteemed hematologists including Dr. S.H. Advani, Dr. Michael Caligiuri, and Dr. M.J. Cline.

With over 25 years of experience in both hematology and oncology, Dr. Ahuja offers a deep well of knowledge and a compassionate approach to patient care at El Portal Cancer Center. His dedication to advancing the field is reflected through active membership in prestigious professional organizations, including the American Society of Hematology, the American Society of Clinical Oncology, the European Society of Medical Oncology, and the Indian Society of Medical and Pediatric Oncology.

A passionate researcher, Dr. Ahuja has contributed significantly to ongoing scientific advancements—serving on the NRG Breast Committee and the Rare Subtype Committee, and acting as Principal Investigator for the “CROWN” NCORP study. His commitment to clinical excellence and groundbreaking research underscores his dedication to improving outcomes for his patients.

Outside of his professional pursuits, Dr. Ahuja values spending quality time with his family, and enjoys hiking and traveling, embracing life outside the clinic with the same dedication he brings to his medical practice. His compassionate nature and extensive experience make him a trusted partner in your cancer care journey.

Dr. Crain is a highly experienced and board-certified Medical Oncologist and Hematologist with over 45 years of dedicated service in the medical field. Throughout his distinguished career, he has established himself as a leading expert in the diagnosis, treatment, and prevention of various cancers and blood disorders.

He earned his medical degree from the University of Illinois College of Medicine in 1977 and is actively affiliated with esteemed institutions, including Adventist Health St. Helena. Dr. Crain’s extensive experience spans a broad range of conditions, including small intestine and colorectal cancers, breast cancer, prostate cancer, anemia, leukemia, and lymphoma.

Beyond his clinical expertise, Dr. Crain is deeply committed to advancing medical research and improving patient care. His approach to treatment is rooted in compassion and a thorough understanding of complex medical conditions, ensuring each patient receives personalized, comprehensive care.

Recognized for his empathetic nature and unwavering dedication, Dr. Crain strives to achieve the best possible outcomes for his patients and foster a trusting, supportive environment. His lifelong commitment to the fields of oncology and hematology reflects his passion for making a meaningful difference in his patients’ lives.

Michael Kangas serves as the Director of Oncology and Diagnostic Imaging, where he spearheads initiatives that enhance revenue, profitability, productivity, and patient satisfaction within an underserved area. His leadership is instrumental in developing and guiding a highly skilled team of healthcare professionals across multiple clinics, providing comprehensive cancer care and diagnostic imaging services utilizing the most advanced technology. Michael’s commitment is rooted in delivering personalized, high-quality care to each patient, ensuring they receive the support they need throughout their journey.

With extensive expertise in Health Information Management, Electronic Medical Records (EMR), Radiation Therapy, Radiation Oncology, Clinical Operations, Healthcare Compliance, and Regulatory Standards, Michael ensures that all services meet the highest industry standards. He also focuses on monitoring performance, healthcare marketing, and supervisory skills to foster a collaborative, efficient, and patient-centered environment.

In addition to his clinical leadership, Michael actively volunteers with the Merced Cancer Society Foundation as its Executive Director. In this role, he oversees key operational and administrative functions to advance the foundation’s mission of positively impacting residents in the Central Valley. His efforts include community outreach, organizing fundraising events, and leading initiatives to expand the foundation’s support and resources for local cancer patients.

Michael’s dedication to improving healthcare and strengthening community ties highlights his unwavering commitment to healing, hope, and making a meaningful difference in the lives of those he serves.

Following your initial consultation with the El Portal team, where your treatment plan is outlined and questions are answered, you’ll be scheduled for a chemotherapy education class. This class will give you essential information about what to anticipate during your treatments, including the duration of appointments, the procedures involved, and resources for addressing questions or side effects after hours.

During this class, you will also meet with a dedicated Patient Financial Counselor who will discuss treatment costs, insurance pre-authorization, and any financial concerns you may have. Once your insurance authorizes your treatment, our office staff will contact you to schedule your first chemotherapy session.

Preparing for Your First Chemotherapy Appointment

Your care team will provide specific instructions for preparing for your first treatment, but in general, preparation is minimal. Drinking plenty of water the day before treatment is recommended, and it is advisable to eat a light meal prior to your appointment. Packing a snack may also help alleviate potential nausea. It’s a good idea to have someone drive you to and from your appointment in case you experience fatigue or nausea afterward.

During your first visit, you will be weighed and have your vital signs checked to ensure it is safe to proceed with chemotherapy. An oncology nurse will insert an IV into your hand or arm, or connect an IV line to your pre-implanted port, if applicable. The chemotherapy drugs will be administered through the IV in a slow, continuous manner. As you receive treatment, you can relax in one of our spacious, light-filled treatment bays equipped with reclining chairs and WiFi access.

Each session may require several hours, so bringing a book or something to watch can make the time more enjoyable. Snacks and water are permitted, and you can make use of the restroom as needed throughout the treatment.

When you’re referred to EPCCC, your medical oncologist and a team of cancer specialists will create a personalized treatment plan tailored to your specific circumstances, considering factors such as:

• Type and grade of your cancer
• Size and location of your tumor
• Sensitivity of surrounding tissues
• Genetic factors
• Family medical history
• Your age, overall health, and previous medical history
• Your treatment goals and preferences

What to Expect During Chemotherapy Treatments

After your initial meeting with your cancer care team to discuss your treatment plan and address any questions, you will be scheduled to attend a chemotherapy education class at El Portal Comprehensive Cancer Centers. This session will provide valuable insights into what you can anticipate from chemotherapy treatment. You will also have the opportunity to meet privately with one of our dedicated cancer financial counselors to discuss treatment costs, insurance coverage, and potential financial assistance.

Your regular chemotherapy treatments will vary based on the specific type of therapy prescribed. Some chemotherapy drugs are given via injection, which is quick, while most are delivered through intravenous infusion, allowing the medication to enter your veins in a slow, continuous manner.

One of the most frequently reported side effects among cancer patients is fatigue. This deep-seated tiredness—often referred to as cancer-related fatigue—can differ significantly from the fatigue experienced by healthy individuals. It can manifest suddenly or gradually, and may not improve with rest. In some cases, fatigue may be compounded by other factors such as anemia and pain. The encouraging news is that this fatigue typically resolves within weeks following the conclusion of treatment.

While side effects will vary by cancer type and individual patient responses, not everyone will experience the same issues. It’s essential to approach this variability with mindfulness and not to expend excessive energy worrying about potential side effects.

Chemotherapy side effects may include:

• Mental fog, often described as “chemo brain,” leading to forgetfulness and difficulty concentrating
• Hair loss
• Easy bruising or bleeding
• Increased susceptibility to infections (bacterial, viral, or fungal)
• Anemia (low red blood cell count)
• Nausea and vomiting
• Loss of appetite
• Constipation and diarrhea
• Pain
• Oral health issues, such as dry mouth, sores, and difficulty swallowing
• Nerve and muscle concerns, including numbness and weakness
• Changes to skin and nails, such as dryness and cracking
• Altered urinary characteristics, affecting color and smell
• Weight loss
• Changes in memory and concentration
• Mood fluctuations
• Alterations in libido and sexual function
• Potential fertility challenges
• Heart-related concerns

In certain cases, chemotherapy may be the sole treatment required. However, it is frequently used in conjunction with other therapies, such as surgery or radiation therapy, to maximize chances of success.

• Neoadjuvant Chemotherapy: Administered before surgery to shrink tumors or halt cancer spread, making surgical procedures less invasive and more effective.
• Concurrent Treatment: Involving chemotherapy or immunotherapy given simultaneously with radiation therapy.
• Adjuvant Chemotherapy: Given after surgery to eliminate any remaining cancer cells, aimed at reducing recurrence risk.

Who Will Oversee Your Chemotherapy?

Your treatment will be overseen by a medical oncologist, a specialist who evaluates your cancer diagnosis and all available treatment options, creating a personalized plan tailored to your needs. As the “quarterback” of your care team at El Portal Comprehensive Cancer Centers, your oncologist will determine chemotherapy’s appropriateness based on several factors, including tumor type, stage, size, and personal considerations.

Your oncologist works alongside a diverse team of healthcare professionals, including radiation oncologists and surgeons, to coordinate your overall care seamlessly. During treatment sessions, a specially trained oncology nurse will administer chemotherapy, monitor your health, address your questions, and assist you in managing any side effects.

Adopting a healthy lifestyle during cancer treatment can help mitigate some side effects and improve your overall well-being. Here are several strategies to consider for managing chemotherapy side effects:

1. Prioritize Rest: Cancer treatment can be exhausting. Make sure to get ample rest, delegate tasks when necessary, and don’t hesitate to ask for help.
2. Stay Active When Possible: While rest is essential, gentle physical activity can enhance energy levels, improve circulation, reduce stress, and maintain muscle strength. Discuss suitable activities with your healthcare provider to find what works best for you.
3. Communicate About Medications: Some medications can interact negatively with cancer treatments. Inform your care team about all the medications you’re taking, including over-the-counter drugs, supplements, and vitamins.
4. Care for Your Skin: If you experience dryness or irritation from treatment, use gentle skincare products. Warm baths with baby oil and fragrance-free lotions can provide relief. Protect your skin from extreme temperatures and stay hydrated.
5. Recognize Your Emotions: The emotional toll of cancer treatment is significant. Feelings of anxiety, anger, sadness, or isolation are common. Engaging with support groups, whether in-person or online, can provide valuable connection and understanding. At El Portal Comprehensive Cancer Centers (EPCCC), we offer resources to help you cope with the emotional aspects of treatment, including support groups and access to licensed clinical oncology social workers. If you find your feelings overwhelming, be sure to discuss them with your care team.

Thanks to recent developments in treatment, many patients find that the severity of chemotherapy side effects has diminished over the years. New medications are also available to help manage side effects, but occasionally, these medications may bring their own challenges.

In certain cases, side effects may signal more serious complications. If you experience any of the following worsening symptoms, please reach out to your care team at EPCCC for guidance (unless experiencing a life-threatening emergency). Our board-certified medical oncologists and specially trained nurses are well-equipped to evaluate your symptoms and recommend appropriate interventions.

If you encounter any of the following issues, our medical professionals are available 24/7 to assist:

• Fever of 100.4°F (38°C) or higher
• Unexplained bruising or bleeding
• Severe rashes or itching
• Swelling in the mouth or throat, along with mouth sores or trouble swallowing
• Swelling in the neck, shoulder, arms, or legs, especially if asymmetrical
• Intense chills
• Unmanaged pain at injection or catheter sites
• Unusual pain, including severe headaches
• Difficulty breathing (immediate emergency care is needed)
• Persistent diarrhea or vomiting
• Blood in stool or urine
• Severe fatigue
• Burning sensation during urination, with lower back pain (potential UTI)
• Productive cough with colored sputum
• Unresolved diarrhea, constipation, nausea, or vomiting
• Dizziness or lightheaded
• Numbness, tingling (feeling of pins and needles) of hands and/or feet