Your Strength. Our Knowledge and Experience.

When faced with a cancer diagnosis, the journey ahead is profoundly influenced by the support of the best doctors, options, and support team who work with you.

Mother with her two daughters
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We see you. All of you.

At El Portal Comprehensive Cancer Centers (EPCC), you will benefit from a dedicated team of doctors, nurses, and treatment professionals united by one common goal: an unwavering commitment to your health and well-being. 

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Your fight is personal for us.

We will deliver personalized, world-class care infused with compassion and kindness. Here, you can trust that you will receive cutting-edge treatment along with the highest quality of care.

Compassionate care is premiere at El Portal Cancer Center in the Central Valley of California
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Choose El Portal Comprehensive Cancer Centers as your trusted partner in this journey.

We are a multidisciplinary practice in Central California dedicated to providing care for patients with cancer and diseases of the blood.

Infusion Services

Our Infusion Center prioritizes your health with a commitment to providing excellent care. The first step towards better health is just a drip away, ensuring that you receive the support and treatment you need to enhance your well-being. Learn More information about Infusion Therapy.

Hematology/Oncology

Chemotherapy, Targeted Therapy, Immunotherapy, Iron (Infed, Venofer, Injectafer,  Feraheme, Monoferric), Therapeautic Phlebotomy

Neurology

IVIG, Tysabri, Solu-Medrol, Ocrevus, Leqembi,  Briumvi, Kisunla

IV Infusion/Injectable

Normal Saline (IV Fluids), IV Antibiotics, Prolia, Reclast, Evenity, Dupixent, & Xolair

Rheumatology

Rituxan, Actemra, & Orencia

Gastroenterology

Remicade, Entyvio, Stelera, Cimzia, & Skyryzi

Wellness

Vitamin C infusions, Myers Cocktail infusions,   Glutathione infusions, NAD+ Booster Infusions,  Inflammation and Detoxifying Treatments, Immune  Boosting Drip Treatments, Skin Rejuvenation   Infusions, as well as B12, Lipo-B, and NAD+   Injections

What our patients have to say...

april B. profile pictureapril B.
21:29 22 May 25
I feel fortunate to have been referred to Dr.M as my hematologist. He's been very attentive, thorough, and caring. He is a great Doctor who cares about his patients. Thank you so much Dr. M for caring, as well as to his staff who've been professional and kind also.
Stella Z. profile pictureStella Z.
15:40 19 May 25
Amazing place, front desk and doctors are friendly.
Neveah profile pictureNeveah
18:55 01 May 25
i love it here the ladies here are so nice and have a gentle hand when it comes to the needle. i feel comfortable and unjudged here and enjoy the time i spend here getting to talk to everyone.
Jaimie C. profile pictureJaimie C.
22:43 30 Apr 25
Love every single one of the girls who work in the infusion room. They do such a great job and always make sure we are comfortable and taken care of.
Natasha G. profile pictureNatasha G.
16:32 24 Apr 25
I can’t say enough great things about this place! From the moment I walked in, the staff made me feel more like family than a patient. Everyone is incredibly friendly, professional, and truly goes above and beyond to make sure you're comfortable. They explain every step of the process in detail, which really helps put your mind at ease.

The iron infusion room is spotless—super clean and sanitized, which I really appreciated. Danica and her amazing team are simply the best. Their care, compassion, and warmth made such a difference during my treatment. Once I’m done, I know I’ll truly miss them.

Thank you to the entire staff for making this experience as smooth and comforting as possible. Highly recommend!
Patricia L. profile picturePatricia L.
21:35 21 Apr 25
Thank you Isabel MA for your amazing help, best communication and treatment I received here much lovely service here
Mychelle C. profile pictureMychelle C.
19:00 26 Mar 25
Danika is awesome!!! She always makes sure to make sure I am as comfortable as possible!! The girls are all amazing!!

Share Your Journey with Us!

At El Portal Comprehensive Cancer Centers (EPCC), we believe that every story matters. Your experiences, struggles, and victories can inspire others who are navigating their own cancer journeys. By sharing your story, you not only help build a supportive community but also empower others to find hope and strength.

Working together to explore treatment options and to create a personalized plan based on your diagnosis and lifestyle.

News | Articles | EVENTS

Dr. Alireza Mahmoudieh, M.D.

Dr. Mahmoudieh has been a vital member of El Portal Comprehensive Cancer Centers since 2008, bringing over a decade of dedicated experience to patient care. Before joining our team, he served as the Director of the Prostate Brachytherapy Program at Kaiser Permanente in Sacramento and Roseville, demonstrating his leadership in advanced cancer treatments.

He earned his medical degree from the Albert Szent-Györgyi School of Medicine in Szeged, Hungary, in 1996. With a strong interest in treating head, neck, and breast cancers, Dr. Mahmoudieh specializes in cutting-edge techniques such as Image-Guided Radiation Therapy (IGRT) and Intensity-Modulated Radiation Therapy (IMRT). His expertise extends to treating cancers of the head and neck, lung, gastrointestinal tract, and prostate.

A committed professional, Dr. Mahmoudieh is a member of the American Society for Therapeutic Radiology and Oncology (ASTRO), reflecting his engagement with ongoing developments in cancer treatment and research. His compassionate approach and advanced skill set ensure that each patient receives personalized, state-of-the-art care.

Outside of his professional life, Dr. Mahmoudieh enjoys traveling with his son and daughter, as well as reading and playing racquetball, embracing a balanced and active lifestyle. His dedication to both his patients and his personal passions makes him a trusted partner in your journey toward health.

Dr. Osman Elhanafy, Ph.D

Dr. Elhanafy is a highly respected Associate Professor of Medical Physics and serves as the Chief Medical Physicist at El Portal Comprehensive Cancer Centers since July 2013. He earned his Ph.D. in Medical Physics from the University of Wisconsin, Madison—where he began his foundational training and completed his thesis—in 2013, building on his initial joining of the university in 1999.

 With specialized training in advanced radiation oncology techniques—such as Intensity-Modulated Radiation Therapy (IMRT), High-Dose Rate Brachytherapy (HDR), Stereotactic Radiosurgery (SRS), Total Body Irradiation (TBI), Quality Assurance, and Radiobiology—Dr. Elhanafy brings a wealth of expertise to patient care. His dedication to the field is evident through numerous published research articles, as well as awards recognizing his leadership in organizing conferences, training sessions, lectures, and workshops.

Beyond his impressive credentials, Dr. Elhanafy is deeply committed to advancing medical physics and ensuring the best possible outcomes for his patients. His compassionate approach, combined with his extensive knowledge, makes him a trusted partner in your cancer care journey.

Outside of his professional pursuits, he values spending quality time with his family, reflecting his genuine care and balance in life.

Dr. Harish Ahuja, M.D.

Dr. Ahuja is a distinguished, board-certified Medical Oncologist with extensive training in medical hematology. He has refined his expertise at renowned institutions such as Tata Memorial Hospital, UCLA School of Medicine, and Roswell Park, under the mentorship of esteemed hematologists including Dr. S.H. Advani, Dr. Michael Caligiuri, and Dr. M.J. Cline.

With over 25 years of experience in both hematology and oncology, Dr. Ahuja offers a deep well of knowledge and a compassionate approach to patient care at El Portal Cancer Center. His dedication to advancing the field is reflected through active membership in prestigious professional organizations, including the American Society of Hematology, the American Society of Clinical Oncology, the European Society of Medical Oncology, and the Indian Society of Medical and Pediatric Oncology.

A passionate researcher, Dr. Ahuja has contributed significantly to ongoing scientific advancements—serving on the NRG Breast Committee and the Rare Subtype Committee, and acting as Principal Investigator for the “CROWN” NCORP study. His commitment to clinical excellence and groundbreaking research underscores his dedication to improving outcomes for his patients.

Outside of his professional pursuits, Dr. Ahuja values spending quality time with his family, and enjoys hiking and traveling, embracing life outside the clinic with the same dedication he brings to his medical practice. His compassionate nature and extensive experience make him a trusted partner in your cancer care journey.

Dr. Sidney Crain, M.D.

Dr. Crain is a highly experienced and board-certified Medical Oncologist and Hematologist with over 45 years of dedicated service in the medical field. Throughout his distinguished career, he has established himself as a leading expert in the diagnosis, treatment, and prevention of various cancers and blood disorders.

He earned his medical degree from the University of Illinois College of Medicine in 1977 and is actively affiliated with esteemed institutions, including Adventist Health St. Helena. Dr. Crain’s extensive experience spans a broad range of conditions, including small intestine and colorectal cancers, breast cancer, prostate cancer, anemia, leukemia, and lymphoma.

Beyond his clinical expertise, Dr. Crain is deeply committed to advancing medical research and improving patient care. His approach to treatment is rooted in compassion and a thorough understanding of complex medical conditions, ensuring each patient receives personalized, comprehensive care.

Recognized for his empathetic nature and unwavering dedication, Dr. Crain strives to achieve the best possible outcomes for his patients and foster a trusting, supportive environment. His lifelong commitment to the fields of oncology and hematology reflects his passion for making a meaningful difference in his patients’ lives.

Michael Kangas

Michael Kangas serves as the Director of Oncology and Diagnostic Imaging, where he spearheads initiatives that enhance revenue, profitability, productivity, and patient satisfaction within an underserved area. His leadership is instrumental in developing and guiding a highly skilled team of healthcare professionals across multiple clinics, providing comprehensive cancer care and diagnostic imaging services utilizing the most advanced technology. Michael’s commitment is rooted in delivering personalized, high-quality care to each patient, ensuring they receive the support they need throughout their journey.

With extensive expertise in Health Information Management, Electronic Medical Records (EMR), Radiation Therapy, Radiation Oncology, Clinical Operations, Healthcare Compliance, and Regulatory Standards, Michael ensures that all services meet the highest industry standards. He also focuses on monitoring performance, healthcare marketing, and supervisory skills to foster a collaborative, efficient, and patient-centered environment.

In addition to his clinical leadership, Michael actively volunteers with the Merced Cancer Society Foundation as its Executive Director. In this role, he oversees key operational and administrative functions to advance the foundation’s mission of positively impacting residents in the Central Valley. His efforts include community outreach, organizing fundraising events, and leading initiatives to expand the foundation’s support and resources for local cancer patients.

Michael’s dedication to improving healthcare and strengthening community ties highlights his unwavering commitment to healing, hope, and making a meaningful difference in the lives of those he serves.

Paul Mosher

Paul I. Mosher is a highly accomplished business professional with extensive experience in healthcare management, medical device sales, and community service. Currently, he proudly serves as the Physician Liaison and Business Development Coordinator at El Portal Comprehensive Cancer Center. In this role, Paul collaborates closely with our dedicated medical team to facilitate patient-centered care, foster strong relationships with our physicians, and support the center’s mission of providing the highest quality cancer treatment.

With expertise in business development, leadership, relationship management, and healthcare technology, Paul is a dedicated and effective communicator committed to exceptional service and compassionate support. His collaborative approach helps ensure that patients receive not only cutting-edge treatment but also personalized care rooted in trust and understanding. Additionally, Paul brings ten years of non-profit experience to our board of directors, furthering his devotion to community health and service.

Paul holds a Bachelor of Business in Business Marketing from Boise State University. He is actively involved in his community, volunteering with various Merced non-profits and churches. Outside of work, Paul enjoys spending quality time with his family and playing golf whenever he can.

Infusion Therapy - Conditions Treated

Infusions are used to treat a wide range of medical conditions, including:

  • Cancer: Chemotherapy agents, targeted therapies, and immunotherapies are often administered via infusion to treat various cancers such as breast, lung, and leukemia.
  • Autoimmune Disorders: Conditions like rheumatoid arthritis, lupus, and multiple sclerosis may be treated with biological agents delivered through infusions to help regulate the immune system.
  • Infections: Severe infections might require antibiotics delivered through infusion for immediate and effective treatment.
  • Nutritional Support: Patients unable to eat or absorb nutrients through the gastrointestinal tract may receive nutritional solutions (Total Parenteral Nutrition, TPN) via infusion.
  • Pain Management: For chronic pain conditions, infusions of medications such as opioids or analgesics may provide relief.
  • Hydration and Electrolyte Replacement: IV fluids are commonly used for rehydration in patients with severe dehydration or electrolyte imbalances.

Risk Factors for Infusion Therapy

While infusion therapy is generally safe, certain factors may increase the risk of complications, including:

  • Allergies:Some patients may have allergic reactions to medications being infused.
  • Infection Risk:The insertion of IV lines can lead to infections if not performed under sterile conditions.
  • Pre-existing Conditions:Patients with compromised immune systems, heart conditions, or kidney issues may face additional risks.
  • Substance Interactions:Patients should disclose all medications, supplements, and herbal products they are taking, as interactions can occur.


Timing of Treatments:
The timing of infusion treatments varies based on the condition being treated:

  • Cancer Patients: Infusion schedules can be based on specific chemotherapy regimens, often occurring every few weeks or as prescribed by an oncologist.
  • Autoimmune Disorders: Infusions may be scheduled monthly or as part of a broader treatment plan based on symptoms and disease activity.
  • Acute Conditions: Infusions for infections or severe hydration may occur as needed, often in a hospital setting.

Side Effects of Infusion Therapy

Side effects of infusion therapy can vary depending on the type of medication and individual patient factors. Common side effects include:

  • Infusion Reactions:Fever, chills, or rashes occurring during or shortly after the infusion.
  • Nausea and Vomiting:Particularly common with chemotherapy agents.
  • Fatigue:Many patients experience tiredness following infusion sessions.
  • Infections:Risks associated with the use of IV lines.
  • Local Reactions: Bruising, swelling, or inflammation at the injection site.

Success Rates of Infusion Therapy

The success rate of infusion therapy depends on several factors, including:

  • Type of Condition: Certain cancer treatments administered via infusion can have high cure rates, especially when applied at early stages.
  • Individual Response: How a patient responds to the specific medication influences effectiveness.
  • Comprehensive Treatment Plan: Optimizing infusion therapy as part of a broader treatment strategy (including surgery, radiotherapy, etc.) can enhance success rates.


For example:

  • Chemotherapy: May lead to significant tumor shrinkage or remission in many cancer patients.
  • Biologics for Autoimmunity: Often result in substantial improvements in symptoms and quality of life for patients with autoimmune diseases.

Accepted Insurance Carriers

AUTHORIZATION REQUIRED: 

  • Alignment Health Plan    
  • AllCare IPA Merced (HMO/NO DERM)  
  • ALLIANCE (CCAH)
  • Anthem MediCAL Managed Care Prog.  
  • Brand New Day-Universal Care, Inc.- Medicare 
  • Calviva Health 
  • Community Care IPA
  • California Forensic Medical Group, Inc  
  • Health Plan of San Joaquin HMO
  • Kova Healthcare, Inc. IPA  
  • Imperial Health Medical
  • MediCAL  
  • Central Valley Medical Providers IPA
  • Sequoia Health IPA 
  • United Healthcare (AARP)
  • Sante Community Physicians  
  • Tricare TriWest Healthare
  • Alliance  
  • Western Growers Assurance Trust  
  • Central Valley Pace County Medical Services Program 
  • Esperanza IPA- Medicare HMO
  • Choice Program
  • HealthNet CA- First Health Hill Physicians 
  • Humana LaSalle Network Management IPA  
  • Meritage Medical Network
  • Seven Corners 


NO AUTHORIZATION REQUIRED: 

  • Aetna
  • Anthem
  • Blue Cross of CA  
  • Blue Shield of CA
  • Medicare 
  • UMR ACPN Network-America’s Choice PN  
  • First Health Network-Cofinity Galaxy Health Network
  • HealthSmart 
  • CIGNA
  • Anthem ACA Plans- Pathway EPO, PPO 
  • BS of CA Promise Health Plan
  • Medicare
  • Railroad Multiplan/PHCS  
  • NaphCare NX Health Network LLC d/b/a Valenz Access 
  • Provider Network of America (PNOA)
  • Wellcare
  • WelbeHealth 

What You Need to Do

  • Verify benefits, plan limits, referral, and pre-authorization requirements before your appointment.
  • Bring your insurance card(s).
  • Notify us of any insurance or personal information changes immediately.
  • Understand your financial responsibility for co-pays, deductibles, and non-covered services.

How EPCC Assists You

  • We verify and review your benefits.
  • We help obtain necessary referrals and authorizations.
  • We provide cost estimates.
  • We inform you about financial assistance options.
  • We bill your primary and, if authorized, secondary insurance.
  • For Medicare patients, supervising physician info will be included on your claims.
  • Our Financial Counselors can provide resources for you to help navigate obtaining traditional insurance coverage 

Your Responsibilities

  • Present your current insurance card at each visit.
  • Keep us updated on insurance info.
  • Pay co-pays at the time of service.
  • Cover any balances remaining after insurance payments.

What to Bring to Your First Visit

Please try to bring the following:

  • Insurance card(s) and referral if required
  • Driver’s license or other photo ID
  • Prescription card
  • Completed new patient forms (if not done online)
  • Relevant medical records, including test results, scans, and reports (some providers may send these directly to us)
  • Contact info for your primary care or referring doctor so we can coordinate your care


Please avoid wearing perfumes, colognes, or heavily scented lotions, as many patients are sensitive to strong smells in the clinic.

Follow-Up Appointments

Before you leave, you can schedule any future appointments needed. These might include:
  • Blood tests
  • Chemotherapy or radiation treatments
  • Follow-up visits with your doctor
  • Additional imaging tests

Our team is always available to help you understand your treatment plan and to answer any questions. During these visits, your care team will review your diagnosis—what type and stage of cancer you have—and discuss your treatment goals. Some cancers may be treated with the aim of curing the disease, while others focus on slowing growth or reducing symptoms.

Insurance & Payment Information

Our friendly and knowledgeable billing team is experienced in helping you understand your insurance benefits, including Medicaid and Medicare coverage for cancer treatments. They can discuss what your insurance may cover and help arrange payment plans for any out-of-pocket costs.

Please note that co-payments may be required at the time of your visit, especially for office visits or treatments like chemotherapy.

We accept cash, checks, and major credit cards—including Visa, MasterCard, Discover, and American Express—to make payments convenient for you.

Questions and Topics

Here are some additional important questions and topics that patients often want to know about during their first appointment:

Understanding Your Diagnosis

  • What does my specific diagnosis mean?
  • How advanced is my cancer, and what stage is it in?
  • What are the possible causes or risk factors?


Treatment Options and Outcomes

  • What treatments are available for my type of cancer?
  • What are the potential benefits and side effects of each option?
  • How effective are these treatments?
  • What is the recommended plan, and why?


Treatment Timeline

  • How long will my treatment last?
  • How often will I need to come in for treatment or appointments?
  • What can I expect during each phase of treatment?


Impact on Daily Life

  • How might treatment affect my daily activities, work, or home life?
  • Are there lifestyle changes I should consider?
  • What kind of support or assistance is available for daily needs?


Managing Side Effects

  • What side effects should I watch for?
  • How can I manage or minimize side effects?
  • When should I contact my care team about specific symptoms?


Support and Resources

  • Are counseling, support groups, or peer resources available?
  • Can I access nutritional guidance or physical therapy?
  • How do I find emotional support during this journey?


Second Opinions

  • Is it advisable to get a second opinion?
  • How can I arrange for one if I choose?


Financial and Practical Concerns

  • What will my treatment cost?
  • Are there financial assistance programs?
  • How do I navigate insurance coverage or billing questions?


Long-term Follow-up

  • What happens after initial treatment?
  • How will I be monitored for recurrence?
  • What signs or symptoms should I watch for in the future?


Personal Questions and Concerns

  • How do I talk to my family about my diagnosis?
  • How can I maintain my mental health and well-being?


Encouraging open dialogue and reassuring patients that asking questions is normal and important can help them feel more comfortable, supported, and engaged in their care.

Difficulty Sleeping / Fatigue

Difficulty Sleeping – Sleep disturbances can occur during treatment, which may exacerbate fatigue. Consider these strategies to improve sleep:

  • Create a calming bedtime routine.
  • Keep your sleeping environment dark, cool, and quiet.
  • Go to bed and wake up at consistent times.
  • Limit screen time before bed and reduce caffeine intake.
  • Discuss melatonin or other sleep aids with your healthcare provider.


Fatigue – Fatigue can be overwhelming and may affect your mental health as well. Strategies for managing fatigue include:

  • Engaging in regular, light exercise to boost energy levels.
  • Practicing yoga or meditation to alleviate emotional stresses.
  • Consulting with a counselor or social worker for additional support.

Hair Loss / Skin Problems

Hair Loss – While hair loss is often associated with cancer treatment, not every patient will experience it. To manage hair loss:

  • Be gentle with your hair care routine and consider head coverings or wigs to boost your confidence.
  • Use cooling caps, if recommended, to possibly reduce hair loss during chemotherapy.
  • Connect with support groups to share experiences and feelings surrounding hair loss.


Skin Problems – Treatments can lead to various skin changes. To care for your skin during treatment:

  • Keep affected areas clean and moisturized with gentle, fragrance-free products.
  • Wear loose-fitting clothing and use sunscreen to protect sensitive skin.

Loss of Appetite / Nausea and Vomiting

Loss of Appetite – Maintaining proper nutrition is vital during treatment. If you experience appetite changes:

  • Opt for smaller, more frequent meals packed with protein.
  • Stay hydrated and ask about anti-nausea medications that can improve your eating experience.
  • Consider discussing dietary changes with a nutritionist.


Nausea and Vomiting – These are common effects of many cancer treatments. To mitigate nausea:

  • Avoid strong scents and stick to bland foods.
  • Maintain hydration, especially with electrolyte drinks if vomiting occurs.
  • Take prescribed anti-nausea medications as directed.

Lymphedema / Managing Pain

Lymphedema – This condition may result from surgery or radiation impacting the lymphatic system. To manage lymphedema:

  • Wear compression garments and consult with a certified lymphedema therapist for specialized care.
  • Regular exercise and gentle stretching can improve lymph fluid drainage.

 

Pain – Managing pain effectively is crucial to your overall well-being. Strategies include:

  • Taking prescribed medications consistently and discussing pain management options with your doctor.
  • Applying heat or ice to areas of discomfort, depending on what provides relief.

What to Expect on Your Journey

  1. Diagnosis
  • The moment you learn about your diagnosis marks the beginning of your journey as a ‘survivor.’
  • We are committed to guiding you through this phase with education about your cancer and the latest treatment options available.
  • Our compassionate team provides personalized, supportive care to help you understand and navigate your diagnosis.
  1. Treatment
  • Your care team will create an individualized treatment plan tailored to your needs.
  • This may include surgery, chemotherapy, radiation, targeted therapies, or immunotherapy—chosen with your health and goals in mind.
  • During this phase, our goal is to provide expert, compassionate support every step of the way.
  1. Life After Cancer (Survivorship)
  • Post-treatment, the focus shifts to helping you regain your strength and reclaim your life.
  • Our team will work with you to develop a tailored plan supporting your physical, emotional, and mental well-being.
  • We understand that life may change after a diagnosis, and we’re here to help you navigate ongoing challenges, including managing long-term effects and emotional stress.

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Our Commitment to Support and Resources

Emotional and Mental Health Support:  Facing cancer can be overwhelming. We offer counseling services and support groups to help you cope with fear, anxiety, and emotional stress. Mindfulness, stress management, and peer support programs are available to guide you through this healing journey.

Physical Wellness and Rehabilitation: Our team provides physical therapy and rehabilitation services to help restore your strength and mobility. Nutrition counseling and lifestyle guidance can support your recovery and long-term health.

Financial and Practical Assistance: Navigating insurance, treatment costs, and other practical concerns can be challenging. Our financial counselors are here to help you understand your options and connect you with assistance programs.

Educational Resources: Stay informed about your health, treatment options, and advances in cancer care through workshops, written materials, and online resources.

Long-term Monitoring: Regular follow-up appointments and screenings are crucial to detect any recurrence early and to monitor effects of treatment.