Your Strength. Our Knowledge and Experience.

When faced with a cancer diagnosis, the journey ahead is profoundly influenced by the support of the best doctors, options, and support team who work with you.

Mother with her two daughters
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We see you. All of you.

At El Portal Comprehensive Cancer Centers (EPCC), you will benefit from a dedicated team of doctors, nurses, and treatment professionals united by one common goal: an unwavering commitment to your health and well-being. 

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Your fight is personal for us.

We will deliver personalized, world-class care infused with compassion and kindness. Here, you can trust that you will receive cutting-edge treatment along with the highest quality of care.

Compassionate care is premiere at El Portal Cancer Center in the Central Valley of California
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Choose El Portal Comprehensive Cancer Centers as your trusted partner in this journey.

We are a multidisciplinary practice in Central California dedicated to providing care for patients with cancer and diseases of the blood.

Infusion Services

Our Infusion Center prioritizes your health with a commitment to providing excellent care. The first step towards better health is just a drip away, ensuring that you receive the support and treatment you need to enhance your well-being. Learn More information about Infusion Therapy.

Hematology/Oncology

Chemotherapy, Targeted Therapy, Immunotherapy, Iron (Infed, Venofer, Injectafer,  Feraheme, Monoferric), Therapeautic Phlebotomy

Neurology

IVIG, Tysabri, Solu-Medrol, Ocrevus, Leqembi,  Briumvi, Kisunla

IV Infusion/Injectable

Normal Saline (IV Fluids), IV Antibiotics, Prolia, Reclast, Evenity, Dupixent, & Xolair

Rheumatology

Rituxan, Actemra, & Orencia

Gastroenterology

Remicade, Entyvio, Stelera, Cimzia, & Skyryzi

Wellness

Vitamin C infusions, Myers Cocktail infusions,   Glutathione infusions, NAD+ Booster Infusions,  Inflammation and Detoxifying Treatments, Immune  Boosting Drip Treatments, Skin Rejuvenation   Infusions, as well as B12, Lipo-B, and NAD+   Injections

What our patients have to say...

april B. profile pictureapril B.
21:29 22 May 25
I feel fortunate to have been referred to Dr.M as my hematologist. He's been very attentive, thorough, and caring. He is a great Doctor who cares about his patients. Thank you so much Dr. M for caring, as well as to his staff who've been professional and kind also.
Stella Z. profile pictureStella Z.
15:40 19 May 25
Amazing place, front desk and doctors are friendly.
Neveah profile pictureNeveah
18:55 01 May 25
i love it here the ladies here are so nice and have a gentle hand when it comes to the needle. i feel comfortable and unjudged here and enjoy the time i spend here getting to talk to everyone.
Jaimie C. profile pictureJaimie C.
22:43 30 Apr 25
Love every single one of the girls who work in the infusion room. They do such a great job and always make sure we are comfortable and taken care of.
Natasha G. profile pictureNatasha G.
16:32 24 Apr 25
I can’t say enough great things about this place! From the moment I walked in, the staff made me feel more like family than a patient. Everyone is incredibly friendly, professional, and truly goes above and beyond to make sure you're comfortable. They explain every step of the process in detail, which really helps put your mind at ease.

The iron infusion room is spotless—super clean and sanitized, which I really appreciated. Danica and her amazing team are simply the best. Their care, compassion, and warmth made such a difference during my treatment. Once I’m done, I know I’ll truly miss them.

Thank you to the entire staff for making this experience as smooth and comforting as possible. Highly recommend!
Patricia L. profile picturePatricia L.
21:35 21 Apr 25
Thank you Isabel MA for your amazing help, best communication and treatment I received here much lovely service here
Mychelle C. profile pictureMychelle C.
19:00 26 Mar 25
Danika is awesome!!! She always makes sure to make sure I am as comfortable as possible!! The girls are all amazing!!

Share Your Journey with Us!

At El Portal Comprehensive Cancer Centers (EPCC), we believe that every story matters. Your experiences, struggles, and victories can inspire others who are navigating their own cancer journeys. By sharing your story, you not only help build a supportive community but also empower others to find hope and strength.

Working together to explore treatment options and to create a personalized plan based on your diagnosis and lifestyle.

News | Articles | EVENTS

How Does Radiation Therapy Work?

During radiation therapy, a team led by a radiation oncologist—a specialist in this treatment—will carefully plan and supervise your treatment. Each session typically involves directing high-energy radiation toward the cancer cells using specialized equipment. This targeted exposure fractures the DNA within the cancer cells, making it difficult for them to grow and multiply. While healthy surrounding cells may also be exposed to some radiation, most can recover and continue functioning normally, whereas cancer cells generally cannot.

At El Portal Comprehensive Cancer Centers, we utilize the latest and most advanced radiation technologies to minimize exposure to healthy cells. Our accredited equipment undergoes daily checks to ensure the highest level of precision in treatment.

Types of Radiation Therapy

There are two main categories of radiation therapy:

External Beam Radiation Therapy

This method delivers radiation from a machine outside the body, directing beams specifically at the cancer site. The equipment does not physically contact the body and can be adjusted to deliver radiation from multiple angles. Treatment typically occurs five days a week for a duration ranging from 1 to 10 weeks.

Technologies may include:

  • TrueBeam Radiotherapy:Offers advanced options tailored to your specific anatomy and cancer type.
  • Image-guided Radiation Therapy (IGRT):Uses imaging (such as CT or ultrasound) to accurately direct radiation.
  • Intensity-modulated Radiation Therapy (IMRT):Shapes radiation beams around tumors while sparing surrounding healthy organs.
  • Stereotactic Radiosurgery (SRS):A non-invasive approach treating irregularly shaped tumors, particularly in the brain.
  • Stereotactic Body Radiation Therapy (SBRT):Similar to SRS, but designed for tumors outside the skull.
  • Hypofractionated Radiation Therapy:A specialized technique for breast cancer treatment, depending on individual patient factors.


Internal Radiation Therapy

Internal radiation therapy, or brachytherapy, involves placing radioactive material directly inside or near the tumor. This may include various implants such as pellets, seeds, or tubes, which are inserted using minimally invasive methods.

At El Portal Comprehensive Cancer Centers, we offer:

  • High-Dose Rate (HDR) Brachytherapy:Often utilized for uterine or cervical cancers, this approach involves placing radioactive material for short durations multiple times.
  • Selective Internal Radiation Therapy (SIRT):An innovative, non-surgical procedure for liver tumors, delivered via tiny radioactive beads inserted directly into blood vessels leading to the tumor.

How Does My Doctor Determined If Radiation Therapy Is Right for Me?

After a cancer diagnosis, you will likely be referred to a cancer specialist, such as a surgical oncologist or medical oncologist. Your treatment plan, which may include radiation therapy, is tailored uniquely based on:

  • Type and grade of cancer
  • Size and location of the tumor
  • Sensitivity of surrounding tissue
  • Genetic components
  • Family history
  • Age, overall health, and medical background
  • Personal treatment goals and preferences


Your doctor will also consider whether you have previously received radiation to that area, as each body part has a safe lifetime dose of radiation. The decision to proceed with radiation for recurrence depends on the location of the tumor, cancer type, and past radiation exposure.

Radiation therapy may be recommended as a standalone treatment or in conjunction with surgeries, chemotherapy, or immunotherapy. At El Portal Comprehensive Cancer Centers, we typically can schedule your first appointment within two days of your referral.

Choosing El Portal Comprehensive Cancer Centers for Radiation Therapy

Radiation therapy demands a high degree of skill, precision, and experience. Selecting a provider with state-of-the-art technology and strict protocols ensuring equipment accuracy is essential.

At El Portal Comprehensive Cancer Centers, we have been delivering high-quality radiation therapy for patients across California for over 15 years. Our board-certified radiation oncologists bring expertise and compassion to your care.

Key factors to consider include:

  • Technology:Choose a center equipped with the most advanced equipment for optimal treatment.
  • Experience:Our dedicated team ensures patients receive knowledgeable and compassionate care.
  • Affordability:As the largest community-based cancer center, we strive to provide services in a cost-effective

Key Lifestyle Choices to Improve Your Well-Being

Physical Activity: Engaging in regular exercise offers numerous benefits such as increased energy, improved mood, weight management, and better cardiovascular health.

  • You don’t need to start with intense workouts; even moderate activities like walking, stretching, or gardening can make a difference.
  • Aim for at least 150 minutes of moderate exercise per week, broken into manageable sessions.
  • Find activities you enjoy to help maintain consistency.


Healthy Eating Habits:
Your diet is a cornerstone of good health. Focus on incorporating a variety of nutritious foods:

  • Vegetables & Fruits: Rich in vitamins, minerals, and antioxidants that support immune health.
  • Whole Grains: Such as brown rice, oats, and whole wheat bread, which provide steady energy and fiber.
  • Lean Proteins: Like poultry, fish, beans, and nuts that help repair tissues and build strength.
  • Limit processed foods, sugary snacks, fast food, and high-fat items, which can contribute to obesity, type 2 diabetes, heart disease, and other health issues.


Avoid Tobacco & Limit Alcohol:
Smoking and vaping pose serious health risks, including increased chances of second cancers.

  • Quitting tobacco dramatically improves health outcomes.
  • While moderate alcohol consumption might be acceptable, overindulgence can undermine your health. The American Cancer Society recommends no more than one drink per day for women and two for men.


Sun Safety: Prolonged and intense sun exposure increases the risk of skin cancer. To protect yourself:

  • Stay indoors during peak sunlight hours (10 a.m. – 4 p.m.).
  • Wear protective clothing, wide-brimmed hats, and sunglasses.
  • Use a broad-spectrum sunscreen with at least SPF 15, reapplying every two hours.


Medication & Medical Follow-Up:
Taking prescribed medicines correctly is crucial for managing health conditions and preventing complications.

  • Don’t discontinue medication without your doctor’s approval.
  • Regular checkups and screenings—such as mammograms, skin exams, or colonoscopies—are critical for detecting any signs of recurrence or new cancers early.
  • Staying vigilant with these appointments is essential, even after completing treatment.

Support, Motivation and Maintaining a Healthy Weight

Transitioning to a new, healthier lifestyle can be challenging, but you don’t have to do it alone. Support groups for cancer survivors provide a safe space to share experiences and encouragement. Family and friends can also offer motivation and accountability. Remember, building healthier routines is a journey—be patient with yourself and celebrate small victories along the way.

Achieving & Maintaining a Healthy Weight

Gaining Weight After Treatment: Some treatments cause nausea, taste changes, and loss of appetite, leading to unintended weight loss. Focus on nutrient-dense, appealing foods—like smoothies, soups, or small frequent meals—to help regain strength.

Losing or Managing Weight: Others may experience weight gain due to medications, inactivity, or stress eating. Developing a balanced diet combined with regular physical activity can help manage weight effectively.

Tips for Weight Management:

  • Track your food and activity to understand your habits.
  • Enlist support from dietitians or healthcare providers for personalized plans.
  • Set realistic, achievable goals.

Dr. Alireza Mahmoudieh, M.D.

Dr. Mahmoudieh has been a vital member of El Portal Comprehensive Cancer Centers since 2008, bringing over a decade of dedicated experience to patient care. Before joining our team, he served as the Director of the Prostate Brachytherapy Program at Kaiser Permanente in Sacramento and Roseville, demonstrating his leadership in advanced cancer treatments.

He earned his medical degree from the Albert Szent-Györgyi School of Medicine in Szeged, Hungary, in 1996. With a strong interest in treating head, neck, and breast cancers, Dr. Mahmoudieh specializes in cutting-edge techniques such as Image-Guided Radiation Therapy (IGRT) and Intensity-Modulated Radiation Therapy (IMRT). His expertise extends to treating cancers of the head and neck, lung, gastrointestinal tract, and prostate.

A committed professional, Dr. Mahmoudieh is a member of the American Society for Therapeutic Radiology and Oncology (ASTRO), reflecting his engagement with ongoing developments in cancer treatment and research. His compassionate approach and advanced skill set ensure that each patient receives personalized, state-of-the-art care.

Outside of his professional life, Dr. Mahmoudieh enjoys traveling with his son and daughter, as well as reading and playing racquetball, embracing a balanced and active lifestyle. His dedication to both his patients and his personal passions makes him a trusted partner in your journey toward health.

Dr. Osman Elhanafy, Ph.D

Dr. Elhanafy is a highly respected Associate Professor of Medical Physics and serves as the Chief Medical Physicist at El Portal Comprehensive Cancer Centers since July 2013. He earned his Ph.D. in Medical Physics from the University of Wisconsin, Madison—where he began his foundational training and completed his thesis—in 2013, building on his initial joining of the university in 1999.

 With specialized training in advanced radiation oncology techniques—such as Intensity-Modulated Radiation Therapy (IMRT), High-Dose Rate Brachytherapy (HDR), Stereotactic Radiosurgery (SRS), Total Body Irradiation (TBI), Quality Assurance, and Radiobiology—Dr. Elhanafy brings a wealth of expertise to patient care. His dedication to the field is evident through numerous published research articles, as well as awards recognizing his leadership in organizing conferences, training sessions, lectures, and workshops.

Beyond his impressive credentials, Dr. Elhanafy is deeply committed to advancing medical physics and ensuring the best possible outcomes for his patients. His compassionate approach, combined with his extensive knowledge, makes him a trusted partner in your cancer care journey.

Outside of his professional pursuits, he values spending quality time with his family, reflecting his genuine care and balance in life.

Dr. Harish Ahuja, M.D.

Dr. Ahuja is a distinguished, board-certified Medical Oncologist with extensive training in medical hematology. He has refined his expertise at renowned institutions such as Tata Memorial Hospital, UCLA School of Medicine, and Roswell Park, under the mentorship of esteemed hematologists including Dr. S.H. Advani, Dr. Michael Caligiuri, and Dr. M.J. Cline.

With over 25 years of experience in both hematology and oncology, Dr. Ahuja offers a deep well of knowledge and a compassionate approach to patient care at El Portal Cancer Center. His dedication to advancing the field is reflected through active membership in prestigious professional organizations, including the American Society of Hematology, the American Society of Clinical Oncology, the European Society of Medical Oncology, and the Indian Society of Medical and Pediatric Oncology.

A passionate researcher, Dr. Ahuja has contributed significantly to ongoing scientific advancements—serving on the NRG Breast Committee and the Rare Subtype Committee, and acting as Principal Investigator for the “CROWN” NCORP study. His commitment to clinical excellence and groundbreaking research underscores his dedication to improving outcomes for his patients.

Outside of his professional pursuits, Dr. Ahuja values spending quality time with his family, and enjoys hiking and traveling, embracing life outside the clinic with the same dedication he brings to his medical practice. His compassionate nature and extensive experience make him a trusted partner in your cancer care journey.

Dr. Sidney Crain, M.D.

Dr. Crain is a highly experienced and board-certified Medical Oncologist and Hematologist with over 45 years of dedicated service in the medical field. Throughout his distinguished career, he has established himself as a leading expert in the diagnosis, treatment, and prevention of various cancers and blood disorders.

He earned his medical degree from the University of Illinois College of Medicine in 1977 and is actively affiliated with esteemed institutions, including Adventist Health St. Helena. Dr. Crain’s extensive experience spans a broad range of conditions, including small intestine and colorectal cancers, breast cancer, prostate cancer, anemia, leukemia, and lymphoma.

Beyond his clinical expertise, Dr. Crain is deeply committed to advancing medical research and improving patient care. His approach to treatment is rooted in compassion and a thorough understanding of complex medical conditions, ensuring each patient receives personalized, comprehensive care.

Recognized for his empathetic nature and unwavering dedication, Dr. Crain strives to achieve the best possible outcomes for his patients and foster a trusting, supportive environment. His lifelong commitment to the fields of oncology and hematology reflects his passion for making a meaningful difference in his patients’ lives.

Michael Kangas

Michael Kangas serves as the Director of Oncology and Diagnostic Imaging, where he spearheads initiatives that enhance revenue, profitability, productivity, and patient satisfaction within an underserved area. His leadership is instrumental in developing and guiding a highly skilled team of healthcare professionals across multiple clinics, providing comprehensive cancer care and diagnostic imaging services utilizing the most advanced technology. Michael’s commitment is rooted in delivering personalized, high-quality care to each patient, ensuring they receive the support they need throughout their journey.

With extensive expertise in Health Information Management, Electronic Medical Records (EMR), Radiation Therapy, Radiation Oncology, Clinical Operations, Healthcare Compliance, and Regulatory Standards, Michael ensures that all services meet the highest industry standards. He also focuses on monitoring performance, healthcare marketing, and supervisory skills to foster a collaborative, efficient, and patient-centered environment.

In addition to his clinical leadership, Michael actively volunteers with the Merced Cancer Society Foundation as its Executive Director. In this role, he oversees key operational and administrative functions to advance the foundation’s mission of positively impacting residents in the Central Valley. His efforts include community outreach, organizing fundraising events, and leading initiatives to expand the foundation’s support and resources for local cancer patients.

Michael’s dedication to improving healthcare and strengthening community ties highlights his unwavering commitment to healing, hope, and making a meaningful difference in the lives of those he serves.

Paul Mosher

Paul I. Mosher is a highly accomplished business professional with extensive experience in healthcare management, medical device sales, and community service. Currently, he proudly serves as the Physician Liaison and Business Development Coordinator at El Portal Comprehensive Cancer Center. In this role, Paul collaborates closely with our dedicated medical team to facilitate patient-centered care, foster strong relationships with our physicians, and support the center’s mission of providing the highest quality cancer treatment.

With expertise in business development, leadership, relationship management, and healthcare technology, Paul is a dedicated and effective communicator committed to exceptional service and compassionate support. His collaborative approach helps ensure that patients receive not only cutting-edge treatment but also personalized care rooted in trust and understanding. Additionally, Paul brings ten years of non-profit experience to our board of directors, furthering his devotion to community health and service.

Paul holds a Bachelor of Business in Business Marketing from Boise State University. He is actively involved in his community, volunteering with various Merced non-profits and churches. Outside of work, Paul enjoys spending quality time with his family and playing golf whenever he can.

Infusion Therapy - Conditions Treated

Infusions are used to treat a wide range of medical conditions, including:

  • Cancer: Chemotherapy agents, targeted therapies, and immunotherapies are often administered via infusion to treat various cancers such as breast, lung, and leukemia.
  • Autoimmune Disorders: Conditions like rheumatoid arthritis, lupus, and multiple sclerosis may be treated with biological agents delivered through infusions to help regulate the immune system.
  • Infections: Severe infections might require antibiotics delivered through infusion for immediate and effective treatment.
  • Nutritional Support: Patients unable to eat or absorb nutrients through the gastrointestinal tract may receive nutritional solutions (Total Parenteral Nutrition, TPN) via infusion.
  • Pain Management: For chronic pain conditions, infusions of medications such as opioids or analgesics may provide relief.
  • Hydration and Electrolyte Replacement: IV fluids are commonly used for rehydration in patients with severe dehydration or electrolyte imbalances.

Risk Factors for Infusion Therapy

While infusion therapy is generally safe, certain factors may increase the risk of complications, including:

  • Allergies:Some patients may have allergic reactions to medications being infused.
  • Infection Risk:The insertion of IV lines can lead to infections if not performed under sterile conditions.
  • Pre-existing Conditions:Patients with compromised immune systems, heart conditions, or kidney issues may face additional risks.
  • Substance Interactions:Patients should disclose all medications, supplements, and herbal products they are taking, as interactions can occur.


Timing of Treatments:
The timing of infusion treatments varies based on the condition being treated:

  • Cancer Patients: Infusion schedules can be based on specific chemotherapy regimens, often occurring every few weeks or as prescribed by an oncologist.
  • Autoimmune Disorders: Infusions may be scheduled monthly or as part of a broader treatment plan based on symptoms and disease activity.
  • Acute Conditions: Infusions for infections or severe hydration may occur as needed, often in a hospital setting.

Side Effects of Infusion Therapy

Side effects of infusion therapy can vary depending on the type of medication and individual patient factors. Common side effects include:

  • Infusion Reactions:Fever, chills, or rashes occurring during or shortly after the infusion.
  • Nausea and Vomiting:Particularly common with chemotherapy agents.
  • Fatigue:Many patients experience tiredness following infusion sessions.
  • Infections:Risks associated with the use of IV lines.
  • Local Reactions: Bruising, swelling, or inflammation at the injection site.

Success Rates of Infusion Therapy

The success rate of infusion therapy depends on several factors, including:

  • Type of Condition: Certain cancer treatments administered via infusion can have high cure rates, especially when applied at early stages.
  • Individual Response: How a patient responds to the specific medication influences effectiveness.
  • Comprehensive Treatment Plan: Optimizing infusion therapy as part of a broader treatment strategy (including surgery, radiotherapy, etc.) can enhance success rates.


For example:

  • Chemotherapy: May lead to significant tumor shrinkage or remission in many cancer patients.
  • Biologics for Autoimmunity: Often result in substantial improvements in symptoms and quality of life for patients with autoimmune diseases.

Types of Gynecologic Cancers

What is Gynecologic Cancer?

Gynecologic cancer refers to cancers affecting the female reproductive system. The five primary types include ovarian, cervical, endometrial, vulvar, and vaginal cancers. Each type presents distinct characteristics, yet early detection remains critical for effective treatment.

Types of Gynecologic Cancers

The six primary types of gynecologic cancers include:

  1. Cervical:Originates in the cervix, the lower end of the uterus leading to the vagina.
  2. Ovarian:Begins in the ovaries, the female reproductive glands located on either side of the uterus.
  3. Uterine (Endometrial):Arises in the uterus, the organ where fetal development occurs.
  4. Vaginal:Develops in the vagina, the channel between the uterus and the outside of the body.
  5. Vulvar:Occurs on the vulva, the external part of the female genitalia.
  6. Tubal:Begins in the fallopian tubes.


While treatment options will vary according to cancer type, tumor grade, and cancer stage, surgery is nearly always a crucial component. Many treatment plans also include chemotherapy and/or radiation therapy. At El Portal Cancer Centers, our team works collaboratively—our surgeon, medical oncologists, and radiation oncologists join forces to ensure you receive the most comprehensive and integrated care possible.

Gynecologic Cancer Risks

What are the Risk Factors?

All women face a risk of developing gynecologic cancers, and this risk increases with age. While some risk factors are controllable, others are not.

Commonly associated controllable risk factors include:

  • Human papillomavirus (HPV) infection
  • Long-term oral contraceptive use
  • Being overweight or obese
  • Poor nutrition
  • Smoking
  • Exposure to diethylstilbestrol (DES)
  • Human immunodeficiency virus (HIV/AIDS) infection

In addition to making lifestyle changes—such as maintaining a balanced diet and exercising regularly—discussing your concerns with your doctor can lead to proactive measures for risk reduction, like the HPV vaccine.

Unfortunately, some risk factors are beyond your control, including age, race, and family history. It’s essential to remember that many women with risk factors never develop gynecologic cancer. If there is a family history of certain cancers, consider discussing genetic testing options with your healthcare provider.

Gynecologic Cancer Symptoms

What Symptoms Should I Watch For?

Being aware of potential symptoms can help facilitate early detection. Some symptoms include:

  • Abnormal vaginal bleeding or discharge
  • Pelvic pain
  • Pain during intercourse
  • Frequent or urgent bowel changes
  • Bloating or a feeling of fullness


If you experience any of these symptoms for more than a month, we strongly recommend scheduling an appointment with your gynecologist. Regular check-ups are vital, even in the absence of symptoms.

What Should I Ask My Doctor?

Establishing an open dialogue with your doctor is crucial for understanding gynecologic cancer. Consider asking:

  • What is a Pap test, and why is it necessary?
  • How often should I schedule Pap tests?
  • What do my Pap results mean?
  • Is an HPV test appropriate for me?
  • When can I discontinue Pap testing?

Gynecologic Cancer Treatments

How are Gynecologic Cancers Treated? A treatment plan for gynecologic cancers is tailored to each individual. Surgery is generally the first step, often followed by a combination of chemotherapy and/or radiation therapy. Our specialists collaborate closely to ensure every aspect of your treatment is addressed thoroughly.

Are All Gynecologic Conditions Cancerous? Not all gynecological conditions are cancerous. Many benign conditions may resolve on their own or can be treated effectively. Examples include fibroids, ovarian cysts, and pelvic infections, each of which may require specific management based on severity.

Robotic-Assisted Surgery and Gynecologic Care

At El Portal Cancer Centers, we offer robotic-assisted surgery, a minimally invasive option that reduces recovery time and minimizes surgical trauma. This advanced approach allows for precise procedures through smaller incisions, resulting in less pain and scarring, lower infection risks, and quicker returns to daily activities.

Minimally Invasive Surgery Options

  • Laparoscopic Surgery:A gold standard in gynecologic procedures, this technique involves small incisions and utilizes a camera to guide the surgeon.\
  • Robotic-Assisted Surgery: A New Era in Gynecologic CareThe landscape of gynecologic surgery has transformed significantly. At El Portal Cancer Centers (EPCC), we are proud to offer robotic-assisted surgery, a forward-thinking option that allows for minimally invasive procedures with enhanced precision and improved outcomes. This advanced technique utilizes specialized robotic instruments coupled with a unique 3D high-definition view of the surgical site, empowering your surgeon to perform with remarkable accuracy.

How Multiple Myeloma is Diagnosed

Diagnosing Multiple Myeloma typically involves several steps:

  1. Medical History and Physical Examination:
    • Your healthcare provider will start by reviewing your medical history, discussing symptoms you’ve experienced, and conducting a thorough physical examination to check for signs of the disease, such as bone tenderness or swelling.
  2. Blood Tests:
    • Blood tests are essential in diagnosing Multiple Myeloma. Common tests include:
      • Complete Blood Count (CBC): Monitors levels of red blood cells, white blood cells, and platelets.
      • Blood Chemistry Tests: Assess kidney function and other vital parameters.
      • Serum Protein Electrophoresis (SPEP): Identifies abnormal proteins (monoclonal proteins) produced by myeloma cells.
      • Free Light Chain Assay: Measures the levels of free light chains in the blood and can indicate the presence of myeloma.
  1. Urine Tests:
    • A 24-hour urine collection may be performed to check for Bence Jones protein, a type of light chain protein released by myeloma cells.
  2. Bone Marrow Biopsy:
    • A definitive diagnosis often requires a bone marrow biopsy, where a small amount of bone marrow (usually from the hipbone) is extracted and analyzed for abnormal plasma cells.
  3. Imaging Tests:
    • Imaging techniques such as X-rays, CT scans, or MRIs are used to assess bone damage or lesions caused by myeloma. These tests help identify areas of bone weakening or fractures.

Causes & Risk Factors of Multiple Myeloma

While the exact cause of Multiple Myeloma remains unknown, several factors may increase the risk:

  1. Age: The risk of developing Multiple Myeloma increases with age, most commonly affecting individuals over 65.
  2. Gender: Men are more likely to develop Multiple Myeloma than women.
  3. Race: African Americans have a higher incidence of Multiple Myeloma compared to Caucasian populations.
  4. Family History: A family history of Multiple Myeloma or related plasma cell disorders may increase individual risk.
  5. Certain Medical Conditions: Conditions such as monoclonal gammopathy of undetermined significance (MGUS) or other blood disorders can predispose individuals to myeloma.
  6. Exposure to Chemicals: Long-term exposure to certain chemicals, such as benzene, and agricultural chemicals, may contribute to the development of myeloma.

Signs & Symptoms of Multiple Myeloma

Recognizing the signs and symptoms of Multiple Myeloma is crucial for early intervention:

  1. Bone Pain: Persistent pain, particularly in the back, hips, or ribs, may indicate damage to the bones caused by myeloma lesions.
  2. Fatigue: Anemia, caused by reduced red blood cell production, often leads to fatigue and weakness.
  3. Frequent Infections: Compromised immune function due to myeloma can make patients more susceptible to infections.
  4. Unexplained Weight Loss: Patients may experience unexplained weight loss with no changes in their regular diet or physical activity.

Multiple Myeloma Treatment Options

Treatment for Multiple Myeloma is generally tailored to individual patient needs and the disease’s specific characteristics. Here are the primary treatment options:

  1. Chemotherapy: Chemotherapy remains a cornerstone of treatment for Multiple Myeloma. Regimens may include combinations such as:
    • Bortezomib (Velcade):A proteasome inhibitor that blocks protein degradation pathways in cancer cells.
    • Dexamethasone:A corticosteroid used in combination with other drugs to reduce inflammation and manage symptoms.
    • Lenalidomide (Revlimid):An immunomodulatory drug that enhances the immune response against myeloma cells.
  2. Targeted Therapy: Targeted therapies focus specifically on cancerous cells, minimizing harm to normal cells:
    • Monoclonal Antibodies:Medications like daratumumab (Darzalex) are designed to target specific proteins on myeloma cells, leading to their destruction.
    • Carfilzomib (Kyprolis):A newer proteasome inhibitor used in patients with relapsed or refractory myeloma.
  3. Immunotherapy: Immunotherapies use the body’s immune system to fight cancer:
    • Chimeric Antigen Receptor (CAR) T-Cell Therapy:This innovative approach involves modifying a patient’s T-cells to better recognize and attack myeloma cells. It has shown promise for some patients with difficult-to-treat myeloma.
  4. Stem Cell Transplant: For eligible patients, stem cell transplant can provide an opportunity for long-term remission:
    • Autologous Stem Cell Transplant:This involves harvesting the patient’s own stem cells, administering high-dose chemotherapy to eliminate cancer cells, and then reinfusing the healthy stem cells.
  5. Radiation Therapy: Radiation can be used to relieve pain or target specific areas affected by multiple myeloma, particularly in cases of localized disease or bone lesions.
  6. Supportive Care: Supportive care plays a vital role in managing symptoms and improving quality of life. This may include medications for pain relief, management of anemia, hydration support, and nutritional counseling.

Types of Bladder Cancer

  1. Transitional Cell Carcinoma (Urothelial Carcinoma): The most common type, originating in the bladder’s inner lining.

  2. Squamous Cell Carcinoma: Less common, often linked to irritation and inflammation of the bladder.

  3. Adenocarcinoma: A rare form that develops from glandular cells in the bladder.

  4. Small Cell Carcinoma: A rare and aggressive type that resembles small cell lung cancer.

Bladder Cancer Diagnosis

  1. Medical History and Physical Examination: A healthcare provider will assess symptoms and perform a physical exam.

  2. Urinalysis: A urine test can reveal blood (hematuria) or abnormal cells.

  3. Cystoscopy: A thin tube with a camera is inserted into the bladder to visually inspect for tumors or abnormalities.

  4. Biopsy: If abnormal tissue is found, a biopsy may be conducted during cystoscopy to confirm the presence of cancer.

  5. Imaging Tests: CT scans, MRIs, or ultrasounds may be used to evaluate the extent of the disease.

Bladder Cancer: Signs, Symptoms, and Risks

Signs and Symptoms

  • Blood in Urine (Hematuria): The most common symptom.
  • Frequent Urination: A strong urge to urinate more often than usual.
  • Painful Urination: Discomfort or burning sensation while urinating.
  • Lower Abdominal Pain: Discomfort in the bladder or pelvic area.
  • Back Pain: Pain in the lower back may also occur in advanced stages.

Risk Factors

  1. Smoking: The leading risk factor associated with bladder cancer.
  2. Chemical Exposure: Contact with certain chemicals, especially in industrial settings.
  3. Chronic Irritation: Repeated urinary tract infections or bladder inflammation.
  4. Family History: A genetic predisposition can increase risk.
  5. Age and Gender: More common in older adults and men.

Bladder Cancer: Potential Treatment Options

This information provides a snapshot of bladder cancer, covering essential aspects for better understanding.

  • Surgery:
    Transurethral Resection (TURBT): A common procedure to remove tumors.
    Cystectomy: Removal of part or all of the bladder in advanced cases.
  • Chemotherapy:
    Used to kill cancer cells or prevent them from growing, either before or after surgery.
  • Immunotherapy:
    Treatments that help the immune system recognize and attack cancer cells.
  • Radiation Therapy:
    Can be used in conjunction with other treatments or for patients who cannot undergo surgery.
  • Targeted Therapy:
    Newer drugs target specific characteristics of cancer cells to block their growth.

Accepted Insurance Carriers

AUTHORIZATION REQUIRED: 

  • Alignment Health Plan    
  • AllCare IPA Merced (HMO/NO DERM)  
  • ALLIANCE (CCAH)
  • Anthem MediCAL Managed Care Prog.  
  • Brand New Day-Universal Care, Inc.- Medicare 
  • Calviva Health 
  • Community Care IPA
  • California Forensic Medical Group, Inc  
  • Health Plan of San Joaquin HMO
  • Kova Healthcare, Inc. IPA  
  • Imperial Health Medical
  • MediCAL  
  • Central Valley Medical Providers IPA
  • Sequoia Health IPA 
  • United Healthcare (AARP)
  • Sante Community Physicians  
  • Tricare TriWest Healthare
  • Alliance  
  • Western Growers Assurance Trust  
  • Central Valley Pace County Medical Services Program 
  • Esperanza IPA- Medicare HMO
  • Choice Program
  • HealthNet CA- First Health Hill Physicians 
  • Humana LaSalle Network Management IPA  
  • Meritage Medical Network
  • Seven Corners 


NO AUTHORIZATION REQUIRED: 

  • Aetna
  • Anthem
  • Blue Cross of CA  
  • Blue Shield of CA
  • Medicare 
  • UMR ACPN Network-America’s Choice PN  
  • First Health Network-Cofinity Galaxy Health Network
  • HealthSmart 
  • CIGNA
  • Anthem ACA Plans- Pathway EPO, PPO 
  • BS of CA Promise Health Plan
  • Medicare
  • Railroad Multiplan/PHCS  
  • NaphCare NX Health Network LLC d/b/a Valenz Access 
  • Provider Network of America (PNOA)
  • Wellcare
  • WelbeHealth 

What You Need to Do

  • Verify benefits, plan limits, referral, and pre-authorization requirements before your appointment.
  • Bring your insurance card(s).
  • Notify us of any insurance or personal information changes immediately.
  • Understand your financial responsibility for co-pays, deductibles, and non-covered services.

How EPCC Assists You

  • We verify and review your benefits.
  • We help obtain necessary referrals and authorizations.
  • We provide cost estimates.
  • We inform you about financial assistance options.
  • We bill your primary and, if authorized, secondary insurance.
  • For Medicare patients, supervising physician info will be included on your claims.
  • Our Financial Counselors can provide resources for you to help navigate obtaining traditional insurance coverage 

Your Responsibilities

  • Present your current insurance card at each visit.
  • Keep us updated on insurance info.
  • Pay co-pays at the time of service.
  • Cover any balances remaining after insurance payments.

Diagnosing Lung Cancer

How is Lung Cancer Diagnosed?

The path to effective treatment begins with an accurate diagnosis of lung cancer. Understanding the tests involved in determining lung cancer type, stage, and whether the disease has spread to other areas of the body is essential.

Lung Cancer Detection and Diagnosis

Early detection is key to successfully treating lung cancer. This is why it is critical for smokers and former smokers to have annual lung screenings, as symptoms often do not manifest until the cancer has reached an advanced stage.

Tests Used for Lung Cancer Diagnosis

A variety of tests help in detecting, diagnosing, and staging lung cancer, as well as in understanding whether the cancer has metastasized to other parts of the body. A biopsy remains the most definitive method for diagnosis, involving the collection of a small tissue sample for laboratory testing. Your doctor will consider several factors when selecting the appropriate diagnostic tests, including the size and location of the suspected cancer, your symptoms, overall health, and prior test results.

Common diagnostic tests include:

  • Chest X-ray:Provides images of the organs and bones in the chest.
  • CT Scan:Offers detailed cross-sectional images of the chest, abdomen, and brain, often with a contrast dye.
  • MRI:Utilizes magnets and radio waves to create detailed images of internal structures.
  • PET Scan:Detects malignant cells by using radioactive glucose, highlighting areas of increased activity.
  • Radionuclide Bone Scan:Identifies cancer cells in the bones through a small injection of radioactive material.


Specific Diagnostic Procedures

Procedures to confirm the diagnosis of lung cancer may include:

  • Fine-Needle Aspiration (FNA) Biopsy:Targets abnormal lung tissue to collect samples for testing.
  • Thoracentesis:Removes fluid to check for cancer cells in the space surrounding the lung.
  • Sputum Cytology:An examination of mucus from the lungs for cancer cells.


Molecular Testing for Non-Small Cell Lung Cancer

Genetic testing is critical for understanding mutations within the cancerous tissue that may respond to targeted therapies. Biomarker testing, such as PD-L1 evaluation, can inform immunotherapy options.

Support for Newly Diagnosed Patients

If you’ve recently received a lung cancer diagnosis, the EPCC team is here to support you every step of the way. We offer access to advanced treatment options and resources designed for you and your loved ones.

Personalized Lung Cancer Treatment Plans

Each treatment plan is individualized based on the type and stage of lung cancer as well as your overall health. Our lung cancer care team collaborates closely to offer the best protocols and recommend a comprehensive treatment plan tailored specifically for you.

Understanding Your Treatment Options

Having open conversations with your oncologist is crucial. We want to ensure you fully comprehend your lung cancer treatment plan, the expected timeline, and how we will monitor its effectiveness. Our lung cancer specialists at EPCC are committed to helping you feel comfortable and confident in your treatment decisions, working alongside you to develop a plan suited to your unique situation.

Together, we can take meaningful steps toward effectively managing lung cancer and improving your quality of life.

Expert Lung Cancer Treatment, Close to Home

At El Portal Cancer Centers, we understand that a lung cancer diagnosis can be a daunting experience. Fortunately, many treatment options are available, and we are dedicated to tailoring these solutions to meet your individual needs and preferences. Our approach is grounded in the specific type and stage of your lung cancer, ensuring that you receive the most effective care possible.

Chemotherapy for Lung Cancer

Chemotherapy is a cornerstone of cancer treatment that utilizes powerful medications to halt the growth of cancer cells, whether by destroying them or preventing their division. Given that lung cancer often spreads rapidly, chemotherapy plays a critical role in many treatment plans, aimed at eradicating these cells.

The administration of chemotherapy can vary based on your specific situation:

  • Systemic Chemotherapy:When the medication is taken orally or injected into a vein or muscle, it enters the bloodstream, reaching cancer cells throughout the body.
  • Regional Chemotherapy:If injected directly into the spinal column, an organ, or a body cavity like the abdomen, this method targets cancer cells in those localized areas.


Chemotherapy Approaches for Small Cell Lung Cancer (SCLC)

Chemotherapy often forms an integral part of the treatment for SCLC, administered in various ways:

  • Chemoradiation:Combining chemotherapy with radiation therapy is commonly recommended for patients with limited-stage SCLC.
  • Primary Treatment:For some patients with advanced SCLC, chemotherapy may serve as the main treatment option.

Chemotherapy and Radiation Therapies

Chemotherapy for Non-Small Cell Lung Cancer (NSCLC)

For patients with NSCLC, chemotherapy may not always be included in the treatment plan, but it can be appropriate in certain scenarios:

  • Before Surgery:Chemotherapy may be utilized to shrink a tumor, paving the way for less extensive surgical intervention.
  • After Surgery:To eliminate any remaining cancer cells that may not be visible through imaging technology, chemotherapy may follow surgical procedures.
  • For Advanced NSCLC:If the cancer has invaded surrounding areas, chemotherapy combined with radiation can be a critical treatment approach, particularly for tumors that have not yet spread to distant organs.


Radiation Therapy for Lung Cancer

There are two primary types of radiation therapy used in lung cancer treatment:

  • External Radiation Therapy:This method employs a machine to direct radiation toward the cancer from outside the body.
  • Internal Radiation Therapy:This involves placing a radioactive substance directly into or near the tumor through sealed needles, seeds, or catheters. Prophylactic cranial irradiation may also be utilized to prevent the cancer from spreading to the brain.


External beam radiation therapy (EBRT) is the most common form used in lung cancer treatment. This procedure targets high-energy beams at the tumor from outside your body, allowing for a treatment experience similar to receiving an X-ray.

Typically, patients undergo radiation sessions once or twice a day, five days a week, over a period of five to seven weeks, depending on the specific goals and stage of treatment.

Advanced Technologies Treatment Options

Advanced Technologies in External Beam Radiation Therapy

At El Portal Cancer Centers, we utilize cutting-edge external beam radiation therapies to enhance treatment effectiveness while minimizing damage to surrounding healthy tissue. Our techniques include:

  • 3-Dimensional Conformal or Intensity-Modulated Radiation Therapy (IMRT):This advanced system uses specialized equipment to break radiation beams into smaller, adjustable segments, ensuring a precise delivery aimed directly at the tumor while sparing healthy areas.
  • Stereotactic Body Radiation Therapy (SBRT):Using advanced imaging techniques, SBRT targets lung tumors with pinpoint accuracy, delivering high doses of radiation in just one to five treatments, ideal for patients who cannot undergo surgery.

Surgery for Lung Cancer

Small Cell Lung Cancer Surgery

Although less common, surgical options may be considered for small cell lung cancer in select cases where the cancer is localized to one lung and nearby lymph nodes. However, due to the nature of SCLC’s rapid spread, surgical intervention is less frequently utilized.

Non-Small Cell Lung Cancer Surgery

Patients diagnosed with early-stage NSCLC are more likely to undergo surgery to remove tumors. As the cancer advances, surgical options may become more complex due to the potential spread throughout the lung(s).

Post-Surgery Considerations

Even if all visible cancer is removed during surgery, your oncologist may recommend chemotherapy or radiation therapy afterward to target any remaining cancer cells. This follow-up treatment is referred to as adjuvant therapy and is essential for reducing the risk of recurrence.

Lung Cancer Treatments by Stage

Understanding your treatment options based on your lung cancer stage is vital. The approach differs significantly between non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). 

Non-Small Cell Lung Cancer: Tailored Treatments by Stage

Understanding the stages of non-small cell lung cancer (NSCLC) is crucial for determining the most effective treatment approach. Each stage presents unique characteristics that guide treatment decisions.

  • Stage 0 In Stage 0, cancer cells are present on the lining of the airway but have not yet invaded the lung tissue. This early stage is highly treatable, often requiring surgery alone to remove the affected tissue. Additionally, laser therapy may be employed to destroy these cancer cells.
  • Stage 1 Stage 1 NSCLC indicates that the cancer has been detected very early, potentially through a lung cancer screening test. Surgical intervention is typically performed to remove the nodule(s). Following surgery, the removed cells undergo testing to determine whether chemotherapy or immunotherapy is needed based on the specific characteristics of the cancer.
  • Stage 2 For patients in Stage 2, surgery is generally recommended to excise the tumor, followed by chemotherapy to eliminate any remaining cancer cells. Depending on the individual case, immunotherapy and targeted drug therapy may also be introduced during this stage, particularly for patients with certain EGFR gene mutations.
  • Stage 3 At Stage 3, surgical options may still be considered; however, the presence of multiple nodules throughout the lungs can complicate effective surgical intervention. In these cases, alternative treatments such as chemotherapy, radiation therapy, immunotherapy, or targeted therapies may serve as first-line options to manage the disease.
  • Stage 4A In Stage 4, cancer has spread beyond the lungs to another part of the body, such as the brain. However, if the cancer has only metastasized to one additional area, surgery may still be an option to remove the tumor from that location. Radiation therapy may also be utilized to address and destroy any remaining cancer cells.
  • Stage 4B Stage 4B indicates that cancer has often disseminated throughout the body or to various sites. In such cases, biomarker testing becomes a valuable tool to identify specific genetic mutations, guiding the use of targeted therapies aimed at halting cancer growth.